SC BIOL 620 - Lectin Pathway (3 pages)

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Lectin Pathway

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Lectin Pathway


Lecture number:
Lecture Note
University Of South Carolina-Columbia
Biol 620 - Immunobiology

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BIOL 620 1st Edition Lecture 9 Outline of Last Lecture I Complement and Functions Outline of Current Lecture II Alternate Pathway III Lectin Pathway IV Regulation of Complement Current Lecture Immunobiology Lecture 10 Classical Pathway and Lectin Pathway Classical Pathway Ag Ab Alternate Pathway Complement activation away from innate system For invertebrates it is default system as it requires no Ag Ab complex but uses pattern recognition microbes have patterns on cells for complements to identify Self cells have high sialic acid in membrane but microbes bacteria fungi and tumor cells have low sialic acid Sialic acid hydrolysis C3b before cascade begins C5a MAC holes drilled into membranes Lectin Pathway No Ag Ab But pattern recognition These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Salmonella listeria HIV mannose exposed on surface Lectin are special proteins that bind carbohydrates MBL mannose binding lectin that binds to exposed mannose and 2 proteins come into play MASP 1 and MASP 2 MBL associated serum protein Complement has ability to kill self cells which are high in sialic acid or not Ag recognized therefore classical pathway activated Regulation of Complement 1 C3b has a short half life needs factor p for stabilizing Sustain level dangerous so very little half life 2 C1 inhibitor dissociates C1r C1s from C1q 3 RCA gene complex regulators of complement activation Large complex inhibited by a Inhibit association b Accelerate dissociation Example DAF decay acceleration factor are membrane bound and release C2a from C4aC2a or release Bb C3bBb complex Therefore C4b and C3b released from membrane 4 HRF homologous restriction factor AKA CD59 clusters of differentiation and cell distinction or cell markers to ID cell or label or bar code HRF binds to C8 and prevents binding of C9 If complement protein of target cell are of same species if not cell lysed Zeno

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