DOC PREVIEW
SC BIOL 620 - Lectin Pathway
Type Lecture Note
Pages 3

This preview shows page 1 out of 3 pages.

Save
View full document
View full document
Premium Document
Do you want full access? Go Premium and unlock all 3 pages.
Access to all documents
Download any document
Ad free experience
Premium Document
Do you want full access? Go Premium and unlock all 3 pages.
Access to all documents
Download any document
Ad free experience

Unformatted text preview:

BIOL 620 1st Edition Lecture 9Outline of Last Lecture I. Complement and Functions. Outline of Current Lecture II.Alternate PathwayIII. Lectin PathwayIV. Regulation of ComplementCurrent LectureImmunobiology Lecture 10- Classical Pathway and Lectin Pathway.Classical Pathway: Ag.AbAlternate Pathway: Complement activation away from innate system. For invertebrates it is default system as it requires no Ag.Ab complex but uses pattern recognition (microbes have patterns on cells for complements to identify).Self cells have high sialic acid in membrane but microbes (bacteria, fungi and tumor cells) have low sialic acid. Sialic acid hydrolysis C3b before cascade begins.C5a –MAC holes drilled into membranes.Lectin Pathway:No Ag.Ab.But pattern recognition.These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.Salmonella, listeria, HIV – mannose exposed on surface.Lectin are special proteins that bind carbohydrates. MBL mannose binding lectin that binds to exposed mannose and 2 proteins come into play MASP 1 and MASP 2 (MBL associated serum protein).Complement has ability to kill self cells which are high in sialic acid or not Ag recognized therefore classical pathway activated.Regulation of Complement:1. C3b has a short half life needs factor “p” for stabilizing. Sustain level dangerous so very little halflife.2. C1 inhibitor dissociates C1r, C1s from C1q.3. RCA gene complex: regulators of complement activation.Large complex inhibited by:a. Inhibit association.b. Accelerate dissociation- Example- DAF (decay acceleration factor) are membrane bound and release C2a from C4aC2a or release Bb C3bBb complex. Therefore, C4b and C3b released from membrane.4. HRF (homologous restriction factor) AKA CD59- clusters of differentiation and cell distinction or cell markers to ID cell or label or bar code.HRF binds to C8 and prevents binding of C9. If complement protein of target cell are of same species,if not cell lysed.Zeno –transplantation: Organs and cells transplant to other species. HRF makes it difficult.Complement Deficiencies:1. SLE “lupus’- high amount of immune complexes in serum. Low C3b and low Cr1 receptor (attaches to RBC and taken to liver).2. Meningitis: Bacteria in meninges of brain. There are high amounts of active complement in brainand attack self.Treatment C1 inhibitor.3. Paroxysmal Nocturnal Hemoglobin urea:Hb in urine due to deficiency of DAF and HRF. Protein coding needs anchor- glycolipid anchor or lipoprotein anchor.Treatment: Monoclonal Ab against C5 (therapeutic Ab).In other words, C5 not substrate for C5 convertase.Complement formed when ruptured skin has clotting cascade as well as complement cascade linked through Plasmin: Plasma accelerates C3 dissociation.Plasminogen ----- Plasmin ---- dissociation C3 to C3a +


View Full Document
Download Lectin Pathway
Our administrator received your request to download this document. We will send you the file to your email shortly.
Loading Unlocking...
Login

Join to view Lectin Pathway and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Lectin Pathway 2 2 and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?