BCHM 3050 1st Edition Lecture 37 Outline of Last Lecture I Stoichiometry of Respiratory Electron Transport II Proton Gradients III Chemiosmotic Theory IV ATP Synthase V Binding Change Mechanism for ATP Synthesis VI Glycerol 3 phosphate Shuttle VII Aspartate Malate Shuttle VIII Reduced Nucleotides Are Not Enough Outline of Current Lecture I How much ATP is produced by the complete oxidation of a hexose II Maximum yield of ATP per molecule of glucose III Production of ATP in liver versus muscle brain cells Current Lecture I How much ATP is produced by the complete oxidation of a hexose a 1 glucose i Substrate level phosphorylation 2 ATP glycolysis ii SLP 2 ATP TCA 2 pyruvates iii NADH 10 iv FADH2 2 v NADH 8 Complex I vi NADH 2 Complex 2 vii FADHs 2 Complex 2 viii ATP 10 2 5 2 1 5 4 b 1 pyruvate i 1 NADH Acetyl CoA ii 3 NADH TCA iii 1 FADH2 iv 1 ATP SLP v ATP 4 2 5 1 1 5 1 12 5 II Maximum yield of ATP per molecule of glucose a Some ATP energy is lost when getting pyruvate into mitochondria b Varying range of ATP produced around 25 29 c Do not get exactly 30 ATP because the process is not fool proof These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute d Some ATP lost as heat e Questions on the test which have to do with the theoretical values III Production of ATP in liver versus muscle brain cells a Liver i NADH 10 Complex 1 10 protons per NADH ii FADH2 2 Complex II 6 protons per FADH2 iii 100 12 112 protons iv 112 4 28 ATP v Theoretical yield 28 4 32 ATP b Muscle Brain i NADH 8 Complex I ii NADH 2 Complex III iii FADH2 2 Complex II iv 8 x 10 80 protons v 2 x 6 12 protons vi 2 x 6 12 protons vii 80 12 12 104 viii 104 4 26 ATP ix Theoretical yield 26 4 30 ATP
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