BMB 401 EXAM III FS14 THIS IS FORM A Please put Form A on your scantron before you begin this exam 1 Please select the True statement regarding the TCA cycle a The reaction catalyzed by citrate synthase requires NAD and produces NADH b Malate dehydrogenase catalyzes an oxidative decarboxylation and produces NADH and CO 2 c Two products of Succinyl CoA synthetase are GTP or ATP and Coenzyme A d Succinate dehydrogenase is a reversible enzyme that produces alpha ketoglutarate and FADH 2 1 2 Please select the true statement regarding regulation of the TCA cycle a Alpha ketoglutarate dehydrogenase activity is increased by high succinyl CoA b Isocitrate dehydrogenase activity is increased by high ATP c Malate dehydrogenase is down regulated by a high ratio of NADH to NAD d The reaction catalyzed by malate dehydrogenase cannot be used to produce glucose 3 What is the correct downstream effect of glucagon a Increase of intracellular cAMP b Phosphorylation of glycogen phosphorylase kinase which increases the activity of this enzyme c Phosphorylation of glycogen phosphorylase which increases the activity of this enzyme d Phosphorylation of glycogen synthase which increases the activity of this enzyme e All the above are true f Only a b and c are true g Only a b and d are true h Only b and c are true 4 Please use the options in Text Box 1 to describe VLDL particles f II IV and VI a I III and VI g II IV and VII b I IV and VI h II V and VII c I IV and VII i III and VI d I V and VI j None of the above e I V and VII Text Box 1 I Produced in the liver II Produced in the small intestine III Carries mostly insulin IV Carries mostly triacylglycerol triacylglyceride V Carries mostly cholesterol and cholesterol esters VI Contains Apo B48 5 Please use the options in Text Box 1 to describe LDL particles a I III and VI f II IV and VI b I IV and VI g II IV and VII c I IV and VII h II V and VII d I V and VI i III and VI e I V and VII j None of the above 6 Which of the following is False regarding familial hypercholesteremia FH a FH FH homozygous individuals have higher serum cholesterol levels even in childhood than normal individuals b In FH FH homozygous individuals LDL receptor concentration at the cell membrane or LDL receptor function may be lower than normal c In FH FH homozygous individuals the high serum cholesterol causes increase of LDL receptor synthesis to bring more cholesterol out of the blood and reduce serum cholesterol BMB 401 EXAM III FS14 d FH heterozygous individuals have higher serum cholesterol levels at middle age than normal individuals 7 The enzyme HMG Co A reductase catalyzes the first committed step of cholesterol synthesis True False 8 The production of cholesterol and the production of ketone bodies both require acetyl CoA True False 2 BMB 401 EXAM III FS14 3 9 In cells that primarily require a great deal of NADPH but not nucleotides which of the pathways in Text Box II will be used in these cells and in what direction Select the correct and most Text Box II complete answer i Oxidative reactions of the pentose phosphate pathway a i only in the forward direction ii Non oxidative reactions of the pentose phosphate pathway b i and ii in the forward direction iii Glycolysis c ii only in the reverse direction iv Gluconeogenesis d i and ii in the reverse direction v The TCA cycle and oxidative phosphorylation e i ii and iv in the forward direction f i ii iii and v in the forward direction 10 Cells engaged in lipid require both NADPH and ATP equally which of the pathways in Text Box II will be used in these cells and in what direction Select the correct and most complete answer a i only in the forward direction b i and ii in the forward direction c ii only in the reverse direction d i and ii in the reverse direction e i ii and iv in the forward direction f i ii iii and v in the forward direction 11 Please select the True statement a In liver cells with high glucose glycogen phosphorylase a will be inhibited b Insulin activation of the insulin receptor results in the phosphorylation of glycogen synthase c Alpha 1 6 glycosidic bonds are broken by glycogen phosphorylase d All the above are true e There are no true statements here 12 In liver the activation of alpha and beta adrenergic receptors by epinephrine has the downstream effect of activating glycogen phosphorylase True False 13 Please identify the true statement a The electron transport chain includes Cytochrome C which is a mitochondrial integral membrane protein b Fumarase catalyzes a stereospecific addition of water across the double bond of malate to make fumarate c Ubiquinol is an uncoupler of oxidative phosphorylation d None of the above is true 14 Please select the True statement a In the malate aspartate shuttle glutamate receives an amino group from aspartate to yield alphaketoglutarate b In the glycerol 3 phosphate shuttle electrons passed from NADH finally enter the electron transport chain through reduction of ubiquinone c In the malate aspartate shuttle oxaloacetate is transported directly into the mitochondrial matrix d None of the above is true BMB 401 EXAM III FS14 15 Glycogen phosphorylase a is phosphorylated and favors the relaxed state whereas non phosphorylated glycogen phosphorylase b favors the tense state True False 4 16 In the muscle glycogen phosphorylase b can be allosterically activated by high AMP True False 17 Three NADH one FADH2 and one ATP or GTP are made per turn of the TCA cycle can produce 10 ATP in the oxidative phosphorylation pathway True False 18 Glucose 6 phosphate is dephosphorylated by glucose 6 phosphatase and released as free glucose by which tissues a Muscles b Liver c Kidneys d Brain e All the above f Only a b and c g Only a and b h Only b and c Text Box III 19 Please state the correct progression of reactions in the following processes in the 1 Oxidation normal forward direction for fatty acid synthesis by using the terms in Text Box III 2 Condensation 3 Hydrolysis a 1 3 1 6 4 Hydration b 1 4 1 6 5 Dehydration c 2 5 2 1 6 Thiolysis d 2 8 5 8 7 Transamination 8 Reduction 20 Please state the correct progression of reactions in the following processes in the normal forward direction for fatty acid catabolism by using the terms in Text Box III a 1 3 1 6 b 1 4 1 6 c 2 5 2 1 d 2 8 5 8 21 Please select the true answer a The fatty acid palmitate is an inhibitor of fatty acid synthesis b Citrate directly inhibits acetyl CoA carboxylase c Citrate inhibits the export of palmitate from the
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