STARTSTARTFOUNDATIONSFOUNDATIONSHow-to 1How-to 1FORMATIONFORMATIONHow-to 2How-to 2SYSTEMSSYSTEMSPROBLEMSPROBLEMSBIOCHEM GENETICS GENOMICSMOL. BIOSTEM CELLS,CLONINGREC. DNACELL TYPE 3DSTRUCTURECELL BIOLVIRUSESCANCERHUMANDISEASELIFELIFENERVOUSFUTUREFUTUREIMMUNESlide 2 - 7.013 - 5/9/07 Virus: from the Latin noun virus, meaning toxin or poison “A virus is a bit of nucleic acidsurrounded by bad news.”Sir Peter MedawarSlide 3 - 7.013 - 5/9/07 Viruses: Size and ShapesSlide 4 - 7.013 - 5/7/07 HerpesSimplexVirusEbola Virushttp://phil.cdc.gov/PHILATTACHMENTEN!DOSOMEESCAPEFig. 13.4 modifiedEndocytosis of virus and escape from endosome/lysosomeSlide 5 - 7.013 - 5/7/07 HIV-1 ON SURFACE OF T CELLSlide 6 - 7.013 - 5/7/07 ATTACHMENTEN!DOSOMEFig. 13.4 modifiedRNAREPLICATION Influenza A Life CycleSlide 7 - 7.013 - 5/7/07 Fig. 19.17The TCR-MHC complex(MHC Class I orMHC Class !II)(CD4 or CD8)(7-11 aa peptide)Slide 8 - 7.013 - 5/9/07Slide 9 - 7.013 - 5/7/07 Vaccine types Example Good BadKilled Salk Polio safe not highly protectiveLive attenuated Sabin Polio mimics disease possible reversionRecombinant Hepatitus safeSOME VIRAL VACCINESImage from: en.wikipedia.org/wiki/Image:Rhinovirus.PNG Surface of the capsid of human rhinovirus 16, one of the viruses which cause the common cold Slide 10 - 7.013 - 5/9/07 Image from: CDC Public Health Image Library (PHIL)Influenza Virus Slide 11 - 5/9/07Influenza Virus1. The HA gene. It encodes the hemagglutinin, which helps virus bind toepithelial cells. 3 distinct hemagglutinins, H1, H2, and H3) are found inhuman infections; 13 others have been found in animal flu viruses.2. The NA gene. It encodes the neuraminidase, which helps virus bud offplasma membrane. 2 different neuraminidases (N1 and N2) havebeen found in human viruses; 7 others in other animals.Two of the RNA molecules encode:Slide 12 - 5/9/07 Genome: 8 different RNA
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