BS 161 1st Edition Lecture 25 Outline of Last Lecture I. Cell cycle IOutline of Current Lecture II. Cell cycle I continuedCurrent Lecture-prophase/prometaphase: nuclear envelope breaks down-metaphase: mitotic spindles must form correctly and connect to chromosomes aligned equidistant from the two poles via kinetochore proteins at the centromere-anaphase: chromatids must separate correctly and move to the poles-telophase: nuclear envelope and nucleolus reforms-microtubules (MTs): tubulin polymers-centrosome: MT organizing center-kinetochores: centromeric protein complexes that function in attaching spindle MTs to the chromatid-spindle: comprised of centrosome, spindle MTs, and asters-MTs change location and abundance in mitotic cell cycle-Important points about cell cycle:-The prokaryotic cell division process is not a good model for eukaryotic cell division.-The four phase cell cycle is similar in all eukaryotic cells.-Chromosome, nuclear and centrosome events must be coordinated in mitosis.-The checkpoint in Gap 1 determines whether a cell will synthesize DNA.-cytokinesis: usually follows mitosis-in animal cells: cleavage furrow of actin and myosin forms a ring around the equatorial region of the dividing cell attached to the plasma membrane-in plant cells: cell plate of cell wall material is built midway between two nuclei by Golgi-derived vesicles collecting on the
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