TAMU BICH 411 - Glycolysis and Fermentation (2 pages)

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Glycolysis and Fermentation



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Glycolysis and Fermentation

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Finishing glycolysis and covering fermentation.


Lecture number:
4
Pages:
2
Type:
Lecture Note
School:
Texas A&M University
Course:
Bich 411 - Comprehen Biochem Ii
Edition:
1

Unformatted text preview:

BICH 411 1st Edition Lecture 4 Outline of Previous Lecture I Glycolysis overview Outline of Current Lecture I Glycolysis Continued II Fermentation III Regulation IV Glycolysis and Cancer V Evolution and glycolysis Current Lecture Act 2 glyceraldehyde 3 P to Glycerate 3 P reactions 6 and 7 ATP is formed for the first time Happens TWICE because the glucose was broken into 2 glyceraldehyde 3 P molecules Reaction 6 Glyceraldehyde 3 P Pi Glycerate 1 3 P2 2 H Glyceraldehyde 3 Phosphate Dehydrogenase GAPDH is the enzyme responsible for this Reduces NAD to NADH This is an electron transfer redox reaction Be able to draw the NAD NADH mechanism as shown in the slides Review the GAPDH mechanism Reaction 7 Glycerate 1 3 P2 Glycerate 3 P ATP Phosphoglycerate Kinase PGK or PK is the enzyme responsible for this This is a Group Transfer reaction phosphate is transferred The phosphate group leaves Glycerate 1 3 P2 and combines ADP to form ATP The glycerate 1 3 P2 stores a lot of energy that is released with the phosphate removal Act 3 glycerate 3 P glycerate 2 P phosphoenolpyruvate Pyruvate reactions 8 10 ATP is formed again These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Reaction 8 Glycerate 3 P glycerate 2 P This occurs with Phosphoglycerate Mutase This is an isomerization reaction The enzyme is phosphorylated on Histidine and switches phosphates with glycerate 3 P the substrate The new phosphate attaches to carbon 2 Reaction 9 Glycerate 2 P Phosphoenolpyruvate The enzyme responsible for this is Enolase This is an elimination reaction Review the enolase reaction The COO activates the removal of an H2O Phosphoenolpyruvate can be used to make various amino acids Reaction 10 Phosphoenolpyruvate Pyruvate ATP Pyruvate Kinase PYK is the enzyme that facilitates this reaction This is a phosphoryl group transfer PYK is a highly regulated enzyme ATP Acetyl CoA and Alanine can inhibit



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