TAMU BICH 411 - Chapter 27: Integration (3 pages)

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Chapter 27: Integration

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Chapter 27: Integration


Covering chapter 27, involving metabolism integration.

Lecture number:
Lecture Note
Texas A&M University
Bich 411 - Comprehen Biochem Ii

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BICH 411 1st Edition Lecture 23 Outline of Last Lecture I Review for exam 3 Outline of Current Lecture I Integration Overview II ATP in metabolism III Adenylate system IV Metabolic Integration V Creatine VI Muscle Protein Degradation VII Liver activity VIII SIR2 gene Current Lecture Figure 27 1 is helpful for understanding how catabolism and anabolism are related with metabolism ATP and NADPH help couple them also note how ATP and NADPH relate photosynthesis and carbon dioxide fixation 10 intermediates connect the catabolic and anabolic systems 4 sugar phosphates 3 alpha keto acids 2 CoA substrates 1 PEP ATP in metabolism there are 3 main types of stoichiometry in the systems reaction stoichiometry seen in general chemistry courses balancing equations etc obligate coupling stoichiometry redox reactions evolved coupling stoichiometry number of ATP molecules involved in pathways ATP coupling determines thermodynamic favorability ex 38 ATPs in glucose oxidation enough to metabolize the glucose but low enough so all glucose is metabolized Coupling coefficient number of moles of ATP used per mole of substrate converted These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute ex with glucose 30 38 ATP pyruvate kinase in glycolysis has 1 since produces 1 ATP ATP has 2 roles in metabolism stoichiometric where ATP is the energy currency allosteric effector tells of the energy status of the cell Good to know for exam Adenylate system involves ATP ADP and AMP all closely controlled and related Adenylate kinase catalyzes phosphorylation of AMP by ATP know this for exam energy charge index to help normalize the energy of the cell to between 0 and 1 know formula for exam in slides if ATP is high energy charge is closer to 1 if ATP is low energy this also helps regulate important enzymes Normal cell energy charge is between 0 85 0 88 know this for the final AMP activated protein kinase

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