TAMU BICH 411 - Nucleotide Synthesis and Degradation (5 pages)

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Nucleotide Synthesis and Degradation

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Nucleotide Synthesis and Degradation


Covering chapter 26, which is nucleotide degradation and synthesis.

Lecture number:
Lecture Note
Texas A&M University
Bich 411 - Comprehen Biochem Ii

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1st Edition BICH 411 Lecture 21 Outline of Last Lecture I Amino acid formation II Amino acid inhibitor herbicides III Amino acid catabolism IV Inborn Errors of Metabolism Outline of Current Lecture I Purine synthesis II Purine degradation III Pyrimidine Synthesis IV Pyrimidine Degradation Current Lecture the ribose of nucleotides can be source of energy think pentose phosphate pathway the purine and pyrimidine rings can t be used for energy Purine Synthesis N1 is from aspartate two other nitrogens N3 and N9 are from glutamine C4 C5 and N7 come from glycine C6 is from CO2 C2 and C8 are from THF figure 26 2 would be a good quiz question IMP is a precursor for AMP and GMP Step 1 ribose 5 phosphate is activated by ATP dependent pyrophosphate addition PP i which makes PRPP Ribose 5 Phosphate pyrophosphokinase is the enzyme in this reaction Step 2 5 phosphoribosyl alpha pyrophosphate PRPP glutamine H2O Phosphoribosylbeta amine glutamate PP The enzyme for this is glutamine PRPP amidotransferase This is the committed step These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Step 3 Phosphoribosyl beta amine glycine ATP Glycinamide ribonucleotide GAR ADP Phosphate The enzyme is GAR synthetase Remember synthetases require ATP synthases don t Step 4 GAR N10 formyl THF FGAR THF The formyl group of N10 formyl THF transfers to GAR to form formylglycinamide ribonucleotide FGAR GAR transformylase is the enzyme Step 5 FGAR ATP Glutamine H2O FGAM ADP glutamate P This forms formylglycinamide ribonucleotide FGAM with the enzyme FGAM synthetase It essentially swaps the carbonyl for N Step 6 FGAM ATP AIR ADP P This forms 5 Aminoimidazole Ribonucleotide AIR with the enzyme AIR synthetase This reaction is similar to step 5 The first ring is built so now we need to build the second ring Step 7 AIR CO2 ATP CAIR ADP P This is a carboxylation reaction using AIR carboxylase to form

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