Chapter 19 MULTIPLE CHOICE Choose the one alternative that best completes the statement or answers the question 1 Which of the following statements about type I reactions is FALSE A Antibodies bind to mast cells and basophils B They involve IgE antibodies C They involve helper T cells D The symptoms occur soon after exposure to an antigen E The symptoms are due to histamine Answer C 2 The symptoms of an immune complex reaction are due to A complement fixation B antibodies against self C phagocytosis D cytokines E destruction of the antigen Answer A 3 In rheumatoid arthritis IgM IgG and complement deposit in joints This is an example of A acquired immunodeficiency B immune complex autoimmunity C cell mediated autoimmunity D cytotoxic autoimmunity E immunosuppression Answer B 4 A healthy immune system destroys cancer cells with A CTLs and activated macrophages B tumor specific antigens C activated macrophages D CTLs E CD T cells Answer A 5 Which of the following is a possible outcome of an HIV infection A Virions may remain latent B Infection may initially be asymptomatic C There may be persistent yeast infections D The disease does not progress to AIDS E All of the answers are correct Answer E 1 6 During asymptomatic phase I of HIV disease HIV infection is diagnosed by A testing for seroconversion B counting CD8 T cells C counting CD4 T cells D measuring viral RNA E measuring antibodies against HIV Answer D Figure 19 1 7 In immune complex reaction shown in Figure 19 1 what is the structure labeled a A mast cell B complement C antibody D neutrophil E antigen Answer E 8 Symptoms of delayed cell mediated reactions are due to A antigens B cytokines C IgE antibodies D IgG antibodies E neutrophils Answer B 9 All of the following are false regarding Herceptin EXCEPT A it is a vaccine to prevent the development of cancer B it neutralizes the growth factor EGF C it acts as an immunotoxin to target and kill cancer cells D it is used to treat some breast cancer patients E it is an endotoxin that stimulates TNF by macrophages Answer D 2 10 All of the following lead to drug induced thrombocytopenic purpura Which occurs first A Antibodies and complement react with platelets B Platelets are destroyed C Drug binds to platelets D Purpura occurs on the skin E Antibodies against haptens are formed Answer C 11 Immunodeficiencies are a result of all of the following EXCEPT A cyclosporine B DiGeorge syndrome C Hodgkin s disease D autoimmune diseases E HIV infection Answer D 12 All of the following are considered examples of type I hypersensitivity EXCEPT A penicillin allergic reactions B transplant rejections C pollen allergies D dust allergies E asthma Answer B 13 Treatment with certain drugs to reduce transplant rejection can cause A immunosuppression B immunotherapy C immunologic enhancement D immunologic surveillance E autoimmunity Answer A 14 Worldwide the primary method of transmission of HIV is A blood transfusions B intravenous drug use C nosocomial D homosexual intercourse E heterosexual intercourse Answer E 15 Which of the following utilizes a combination of monoclonal antitumor antibody and immunotoxin A immunologic enhancement B immunotherapy C immunosuppression D immune complex E immunologic surveillance Answer B 3 16 Which of the following types of transplant is least compatible A isograft B allograft C autograft D xenotransplant E All of these types of tranplant are equally compatible Answer D 17 Desensitization involves injection of A IgG antibodies B histamine C IgE antibodies D antigens E antihistamine Answer D 18 Hemolytic disease of the newborn can result from an A Rh mother with an Rh fetus B Rh mother with an Rh fetus C Rh mother and an A fetus D AB mother with an O fetus E AB mother with a B fetus Answer A 19 The chemical mediators of anaphylaxis are A found in basophils and mast cells B antibodies C the proteins of the complement system D antigens E antigen antibody complexes Answer A 20 Which of the following statements about type IV reactions is FALSE A Reactions are primarily due to T cell proliferation B Allergic contact dermatitis is an example C Hemolytic disease of the newborn is an example D Cytokines initiate tissue damage E Reactions are not apparent for a day or more Answer C 21 Which antibodies will be in the serum of a person with blood type B Rh A anti A anti Rh B anti A anti B anti Rh C anti B anti Rh D anti A E anti B Answer D 4 22 Which of the following regions has the greatest distribution of HIV infection and AIDS in the world A South and Southeast Asia B Eastern Europe and Central Asia C sub Saharan Africa D Latin America E North America Answer C 23 Graft versus host disease will most likely be a complication of a n A corneal transplant B skin graft C bone marrow transplant D blood transfusion E Rh incompatibility between mother and fetus Answer C 24 The number of T cells drops to below 200 cells microliter in which phase of HIV infection A phase 1 B phase 2 C phase 3 D initial phase E asymptomatic phase Answer C Table 19 1 Donor Recipient 1 AB Rh2 A Rh AB Rh A Rh 3 A Rh 4 B Rh O Rh B Rh 5 B Rh A Rh 25 Which blood transfusions in Table 19 1 are incompatible A 3 and 4 B 1 2 and 3 C 2 3 and 5 Answer C 26 Allergic contact dermatitis is due to A IgE antibodies B activated macrophages C sensitized T cells D IgG antibodies E IgM antibodies Answer C 5 D 1 and 2 E 2 and 5 27 A positive tuberculin skin test is an example of A psoriasis B innate immunity C acute contact dermatitis D delayed cell mediated immunity E autoimmunity Answer D 28 The process of desensitization to prevent allergies involves the injection of increasing amounts of A antihistamine B antigen C RhoGAM D IgE E IgG Answer B 29 Rheumatoid arthritis is due to deposition of A IgD and IgE complexes in joints B IgA antibodies in joints C IgG and IgA complexes in joints D complement in joints E complexes of IgM and IgG and also complement in joints Answer E 30 Chemotherapy to inhibit the progression of HIV infection utilizes all of the following mechanisms EXCEPT A inhibition of viral proteases B termination of viral DNA C destruction of viral ribosomes D prohibition of viral integration into host cell DNA E blockage of viral attachment Answer C 31 Which of the following statements about human embryonic stem cells is FALSE A They express no MHC II antigens B They are typically obtained from the blastocyst stage of embryonic development C They are pluripotent D They are undifferentiated E They express few