DOC PREVIEW
UIUC MCB 450 - Fatty Acid Metabolism

This preview shows page 1 out of 2 pages.

Save
View full document
View full document
Premium Document
Do you want full access? Go Premium and unlock all 2 pages.
Access to all documents
Download any document
Ad free experience
Premium Document
Do you want full access? Go Premium and unlock all 2 pages.
Access to all documents
Download any document
Ad free experience

Unformatted text preview:

MCB 450 1st Edition Lecture 20Outline of Last Lecture I. Proton-Motive Force hypothesisII. ATP synthase: Compositions, how it works.III. P/O ratio and the final ATP countIV. Shuttle systemsV. Uncouplers of oxidation phosphorylationOutline of Current Lecture I. Fatty acid catabolism:a. β-oxidation of saturated (even C) fatty acids and the ATP count b. β-oxidation of saturated (uneven C) fatty acidsc. β-oxidation of polyunsaturated fatty acidsd. Ketone bodiesII. Fatty acid biosynthesisa. Overviewb. How the cell ensures supply of the precursors acetyl-CoA and NADPHc. Steps of biosynthesisd. Overall equation for the synthesis of one molecule of palmitic acid (16:0)e. Regulation of fatty acid metabolism (allosteric, covalent, hormonalCurrent LectureLipid Degradation-Phosphorylation of perilipin restructures the lipid droplet and releases the coactivator ofATGL-The activation of ATGL by binding with its coactivator initiates the mobilization-Then hormone sensitive lipase releases a fatty acid from diacylglycerol-Monoacylglycerol lipase completes the mobilization process-ATGL -- adipose triglyceride lipase-HS lipase -- hormone sensitive lipase-MAG lipase -- monoacylglycerol lipaseOne cycle of beta-oxidation - for saturated FA-One beta-oxidation cycle will shorten the chain by two carbons and will generate FADH2, NADH, and acetyl CoAHow are odd-carbon fatty acids oxidized?-The oxidation of odd-carbon fatty acids and fatty acids that have double bonds require extra stepsThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.-An isomerase and reductase are required -Odd-carbon fatty acids yield propionyl CoA in the final thiolysis stepKetone Bodies-Ketone bodies -- acetoacetate, 3-hydroxybutyrate, and acetoneDiabetic ketosis results when insulin is absent-Diabetes can lead to a life-threatening excess of ketone-bodiesGlucagon/epineprhine-Glucagon will switch off fatty acid synthesis-Insulin will switch on fatty acid


View Full Document

UIUC MCB 450 - Fatty Acid Metabolism

Download Fatty Acid Metabolism
Our administrator received your request to download this document. We will send you the file to your email shortly.
Loading Unlocking...
Login

Join to view Fatty Acid Metabolism and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Fatty Acid Metabolism 2 2 and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?