MCB 450 1st Edition Lecture 18Outline of Last Lecture I. Overview of the process of complete oxidation of glucose (glycolysis + TCA Cycle + Oxidative Phophorylation)II. Preparatory step for TCA Cycle (Pyruvate Acetyl CoA)III. Reactions of the TCA Cycle (8)IV. Regulation of the TCA CycleV. TCA Cycle can also provide precursors for biosynthesisVI. Anaplerotic reactionsVII. The glycoxylate cycleOutline of Current Lecture I. Oxidation-Reduction reactionsII. Defnition of ξ° (standard reduction potential)′III. Organization of the ETC is according to increasing ξ values.′IV. The components of the mitochondrial ETCV. The path of e- flow and concomitant H+ transfer in the ETC.VI. ROSCurrent LectureThe Glycoxylate Cycle-Occurs in glyoxysomesOverview of the process of complete oxidation of glucose under aerobic conditions-Conversion of glucose to pyruvate occurs in cytosol -Light blue box occurs in the matrix and the right half is in the inner membraneMitochondrial functions are localized in specifc compartments (eukaryotes)-The TCA cycle and FA oxidation occur in the matrix-Oxidative phosphorylation occurs in the inner membrane and inner membrane spaceStandard Reduction Potential values can be used to predict the direction of redox reactions-The more positive the E value the better the oxidizing agent the substance is -The more negative the E value the better the substance is as a reductantRelation between the standard reduction potential and delta-G of a redox-If given a redox potential should be able to calculate the delta-GElectrons flow down an energy gradient-Energy is released when high-energy electrons are transferred to oxygen-The energy is used to establish a proton gradientComplex III - Q-Cytochrome C OxidoreductaseThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.-Fully oxidized becomes semiquinone radical ion Q--Second half of Q cycleoSemiquinone radical ion Q- becomes fully reduced ubiqual-1 OH2 = 1 NADH or 1 FADH2Complex IV (Cytochrome c Oxidase) - Summary-4e- is equivalent to : 2 NADH, 2 FADH2 or (1 NADH + 1
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