Machinery Energetics of Muscle Contraction 1 Thick filament 2 Thin filament 3 is like double headed golf club 4 is like a double strand of pearls 5 is the large protein molecule attached to actin ends 6 is the rod shaped protein that covers the myosin binding sites on the actin strand 7 moves tropomyosin out of the way of the myosin binding sites 8 Going from a high energy state to a low energy state and moving actin forward 9 When myosin heads bind to actin it acts as which splits ATP and provides energy 10 At the low energy state myosin heads are 11 At the high energy state myosin heads are 12 Terminal cisterna contain percent of Ca 2 for muscle contractian whereas extracellular fluid contain percent of the Ca 2 13 Whole purpose of Excitation is just to intracellular Ca 2 14 Put the following events of sliding filament mechanism in chronological order 1 myosin heads bind with actin and form crossbridge 2 intracellular Ca 2 moves tropomyosin out of way of myosin binding sites 3 myosin head moves to low energy configuration 4 crossbridge acts as an ATPase splits ATP 5 head returns to high energy configuration and forms crossbridge further back on actin 15 What is the currency of muscle configuration 16 Name 3 places we have stores of ATP 17 These stores of ATP are for contraction only 18 What cycle creates 32 ATPs 19 What molecule undergoes glycolysis to create pyruvic acid for running the Krebs Cycle 20 Starting with a molecule of glucose going through the Krebs Cycle how many ATPs could be generated 21 Starting with a molecule of glycogen going through the Krebs Cycle how many ATPs could be generated 22 No oxygen is required for metabolism and only number of ATPs can be generated per molecule of glucose 23 The splitting of glucose 24 The Krebs Cycle depends on metabolism ANSWERS 1 myosin 2 actin 3 myosin heads 4 actin 5 troponin 6 tropomyosin 7 Ca 2 8 power stroke 9 ATPase 10 horizontal 11 cocked straight up 12 80 20 13 increase 14 2 1 4 3 5 15 ATP 16 myosin heads creatine phosphate glycogen 17 short term 18 Kreb Cycle 19 glucose 20 34 ATPs 21 35 ATPs 22 anaerobic 2 23 glycolysis 24 aerobic
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