Machinery & Energetics of Muscle Contraction1. Thick filament =2. Thin filament = 3. __________ is like double-headed golf club4. __________ is like a double strand of pearls5. __________ is the large protein molecule attached to actin ends.6. __________ is the “rod-shaped” protein that covers the myosin binding sites on the actin strand.7. ______ moves tropomyosin out of the way of the myosin binding sites.8. Going from a high energy state to a low energy state and moving actin forward = ?9. When myosin heads bind to actin, it acts as _________ which splits ATP and provides energy.10. At the low energy state, myosin heads are __________.11. At the high energy state, myosin heads are _______.12. Terminal cisterna contain ____ percent of Ca+2 for muscle contractian, whereas extracellular fluid contain ____ percent of the Ca+2.13. Whole purpose of Excitation is just to ________ intracellular Ca+2.14. Put the following events of sliding filament mechanism in chronological order: 1. myosin heads bind with actin and form crossbridge 2. intracellular Ca+2 moves tropomyosin out of way of myosin binding sites 3. myosin head moves to low energy configuration 4. crossbridge acts as an ATPase & splits ATP 5. head returns to high energy configuration and forms crossbridge further back on actin15. What is the currency of muscle configuration?16. Name 3 places we have “stores” of ATP.17. These stores of ATP are for _____________ contraction only.18. What cycle creates 32 ATPs?19. What molecule undergoes glycolysis to create pyruvic acid for running the Krebs Cycle?20. Starting with a molecule of glucose & going through the Krebs Cycle, how many ATPs could begenerated?21. Starting with a molecule of glycogen & going through the Krebs Cycle, how many ATPs could be generated?22. No oxygen is required for _______________ metabolism, and only _____ number of ATPs can be generated per molecule of glucose.23. The splitting of glucose = _________________.24. The Krebs Cycle depends on _______________ metabolism.ANSWERS1. myosin2. actin3. myosin heads4. actin5. troponin6. tropomyosin7. Ca+28. power stroke9. ATPase10. horizontal11. cocked (straight up)12. 80% / 20%13. increase14. 2 – 1 – 4 – 3 - 515. ATP16. myosin heads, creatine phosphate, & glycogen17. short-term18. Kreb Cycle19. glucose20. 34 ATPs21. 35 ATPs22. anaerobic / 223. glycolysis24.
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