2. Calculate the ke of a 56 year old, 79 kg male patient with a serum creatinine of 1.6 mg/dL who requires an aminoglycoside treatment. [Use ke= 0.00293 (CrCL)+0.014 hr-1].PHA 5127 Answers Case Study 4 Fall 2007 1. For the following situations, indicate whether the drug is filtered, reabsorbed or actively secreted (Assume GFR is 130 mL min-1, urine flow is 1.5 ml min-1) • A drug with fu = 0.02and a ClREN = 20 mL min-1 is _______________________ (GRF*fu=2.6 < Clren, Secreted) • A drug with fu = 0.40 and a ClREN = 52 mL min-1 is _______________________ (GFR*fu=52 = Clren, Filtered) • A drug with fu = 0.30 and a ClREN = 0.45 mL min-1 is _______________________ (GFR*fu=39 > Clren= Urine flow*fu=1.5*.3, Complete Reabsorbed) 2. Calculate the ke of a 56 year old, 79 kg male patient with a serum creatinine of 1.6 mg/dL who requires an aminoglycoside treatment. [Use ke= 0.00293 (CrCL)+0.014 hr-1]. -1 -1:with Cockcroft-Gault Equation (140- ) /(72 ) (140-56) 79 / (72 1.6) 57.6 / min 0.00293 ( ) 0.014 0.183SolutionCLCr age Wt SerumCr mlke CrCL h h = • • = • • = = + = 3. Mark whether the following statements for a high extraction drug are True or False intintHuHHuQfClCl QQfCl••=≈+• intint1uHufClEQfCl•=≈+• int1HuQFEfCl=− ≈• T F The oral bioavailability (F) will be close to 1. (F) T F Clearance will increase significantly after induction of the relevant enzyme. (F) T F The hepatocyte membranes do not represent a barrier. (T) 4. Mark whether the following statements are True or False T F a. Since creatinine is endogenous and predominantly eliminated by kidney, its clearance is a good estimation of renal active secretion. (F) T F b. Creatine clearance can only be used to estimate the renal clearance of drugs that are similar to creatine, which does not show plasma albumin binding. (F)T F c. “Linear pharmacokinetics” means that the plasma drug concentration versus time plots will result in a straight line.
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