PHA 5127 (Fall, 2008) Case Study #1 Questions Q1. 800 mg of drug X was administrated to a patient through i.v. bolus. The drug plasma concentrations monitored after injection are listed in the table below. Time (min) Conc. (mg/l) 2 72.9 7 57.9 15 40 30 20 60 5 a) Please state whether the drug follows a zero- or a first-order elimination process. b) Estimate the elimination rate constant (ke) and half-life (T1/2). c) Estimate the initial plasma drug concentration (C0) and volume of distribution (Vd). d) Estimate the initial plasma drug concentration (C0) and AUC0-inf. e) Predict the drug plasma concentration 2 hrs after the injection (C120).Q2. Please fill in the missing numbers! Extracellular Fluid Intracellular Fluid Plasma Water Interstitial Fluid Total Body Water Q3. Mark each of the following statements True or False. T F For a first-order elimination process, the same amount of drug is eliminated during a given time interval. T F For a zero-order elimination process, the half-life (t1/2) depends on the drug concentration. T F In a perfusion limited distribution, tissue membrane represents no barrier for the drug diffusion. T F In a permeability limited distribution, blood flow is not important for rate of uptake. T F Volume of distribution is the real tissue volume that contains the drug. Q4. Define the term biopharmaceutics and
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