PHA 5127 – Fall 2006 Case Study #2 #1: Please fill in the missing numbers! Total Body Water Extracellular Fluid Intracellular Fluid Plasma Water Interstitial Fluid #2: The volume of distribution (Vd) of a lipophilic drug A is 800L. Answer the following questions with true or false! a) Drug A is able to cross membranes b) Drug A does not show any tissue protein binding c) Plasma protein binding is more pronounced than tissue binding d) Vd indicates that this drug is highly metabolized in the tissue e) Drug A does not leave the plasma f) Vd does reflect a real volume #3: Basics and Background of Vd. a) Give a definition of the Volume of distribution in your own words and give additionally the formula used for calculations. b) Patient H. was given 100mg of drug M intravenously. His plasma levels are listed below. Please calculate Vd! Time (h) Cp (μg/L) 1.5 171 4 119 6 79.5 7.5 51 10 1#4: Quinidine has a plasma protein binding, ranging from 70-90%. In patients with chronic liver disease plasma protein binding is decreased by 20%. How will the volume of distribution change? Use a plasma volume of 3 L and the fraction bound in plasma 85% (for normal patients), a tissue volume of 38 L and the fraction unbound in tissue 30% to calculate the volume of distribution in patients with liver
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