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UF PHA 5127 - PHA 5127 Final Exam

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Name UFID PHA 5127 Final Exam Fall 2009 On my honor I have neither given nor received unauthorized aid in doing this assignment Name Please transfer the answers onto the bubble sheet The question number refers to the number on the bubble sheet Please fill in all the information necessary to identify yourself The proctors will also collect your exams Good LUCK TOTAL 120 pts 1 Name UFID Question set I 10 pts Select whether the following statements are True A or False B concerning a drug that is absorbed by a first order process and eliminated by a first order process 1 T F The faster the absorption the shorter will be tmax 2 T F The faster the absorption the lower will be Cmax 3 T F The smaller ka the smaller the fluctuation between peak and trough concentration when given twice daily 4 T F Assume that all the drug will dissolve in time to enter the portal vein For a high extraction drug an increase in ka tends to decrease the oral bioavailability 5 T F Assume that all the drug will dissolve in time to enter the portal vein For a low extraction drug the oral bioavailability will increase with increasing ka 2 Name UFID Question set II 6 pts Select from the following statements whether the statements are True A or False B 6 T F Assume steady state has been reached after having started a constant rate infusion At steady state k0 will equal clearance 7 T F The time to reach steady state after an constant rate infusion is affected by the clearance and volume of distribution of the drug 8 T F Drugs showing a high degree of accumulation after multiple iv bolus injections will need a long time to reach steady state when the drug is given as a constant rate infusion no loading dose is given Question set III 4 pts Select from the following statements whether the statements are True A or False B Assume a multiple dosing situation 9 T F For a lipophilic drug whose clearance is constant under the given conditions the following statement can be made The stronger the tissue binding the more pronounced the degree of accumulation 10 T F For a lipophilic drug whose clearance is constant under the given conditions the following statement can be made The stronger the tissue binding the more pronounced the fluctuation between peak and trough concentration 3 Name UFID Question set IV 20 pts The following applies to questions 11 14 A 60 kg patient is to be started on a continuous intravenous infusion From a previous regimen of the same drug you estimate the patient s ke is 0 07 h 1 and the Vd is 40 L Assume that none of this drug has been administered this month Question 11 What rate of infusion k0 for the following constant rate infusion should result in a Cpss of 20 mg L Round appropriately 5 pts A 56 mg 0 5 hours B 28 mg 0 5 hours C 28 mg hr D 28 mg E none of the above 4 Name UFID A 60 kg patient is to be started on a continuous intravenous infusion From a previous regimen of the same drug you estimate the patient s ke is 0 07 h 1 and the Vd is 40 L Assume that none of this drug has been administered this month Question 12 If the Cpss is to be 20 mg L what should be the loading dose mg given as intravenous bolus injection Round appropriately 5 pts A 400 mg B 800 mg C 1200 mg D 1220 mg E none of the above 5 Name UFID A 60 kg patient is to be started on a continuous intravenous infusion From a previous regimen of the same drug you estimate the patient s ke is 0 07 h 1 and the Vd is 40 L Assume that none of this drug has been administered this month Question 13 What will be the plasma concentration 1 hour after start of the continuous infusion remember a loading dose was given Round appropriately 5 pts A 3 9 mg L B 4 0 mg L C 3 6 mg L D 20 mg L E None of the above 6 Name UFID A 60 kg patient is to be started on a continuous intravenous infusion From a previous regimen of the same drug you estimate the patient s ke is 0 07 h 1 and the Vd is 40 L Assume that none of this drug has been administered this month Question 14 The infusion is continued for 3 days and the steady state concentration has been maintained at 20 mg L The physician wants to change the drug delivery to multiple short term infusions with a Cmax of 20 mg L and a trough of 10mg L Hint The first short term infusions should be administered when the remaining plasma concentration reaches 10 mg L How many hours after the continuous infusion has been stopped should the first short term infusion be given Round appropriately 5 points A 1h B 2h C 8h D 10 h E None of the above 7 Name UFID Question set V 5 pts Question 15 A 60 kg patient is started on 80 mg of gentamicin every 6 hr given as a one hour infusion Assume that steady state has been reached for this multiple dosing situation If this patient is assumed to have an average volume of distribution value of the population mean of 0 25 L kg and a normal half life of 3 hr what would be the plasma concentration 1 hour before the start of the next infusion Round appropriately 5 points A 3 2 mg L B 2 5 mg L C 0 8 mg L D 1 2 mg L E None of the above 8 Name UFID Question set VI 5 points Question 16 A 60 kg patient is started on 80 mg of drug X every 6 hr given as a one hour infusion The half life of this drug is 4 hours If the infusion is given the first time how much lower is the first peak when compared to the Cmax at steady state Cmax ss A 30 40 of Cmax ss B 41 50 of Cmax ss C 61 75 of Cmax ss D None of the above E Don t have enough information to provide this information 9 Name UFID Question set VII 10 pts Consider the following equation Cpmin ko 1 e ke T ke t e ke CL 1 e Select the true statements concerning the following part of the equation 10 points 1 e 17 T F k e T This parts provides information on how much the first Cmax after the first short term infusion is away from the steady level of a continuous infusion using the same ko 18 T F This part allows the calculation of the trough concentration after the stop of the infusion as it converts the peak levels into the trough value 19 T F This part makes sure …


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