Question 12 For multiple iv bolus injection one can state (1Name: ____________________ UFID#: ______________________ PHA 5127 Final Exam Fall 2005 On my honor, I have neither given nor received unauthorized aid in doing this assignment. Name Please transfer the answers onto the bubble sheet. The question number refers to the number on the bubble sheet. Please fill in all the information necessary to identify yourself. The proctors will also collect your exams. Good LUCK. Question/Points TOTAL _______/200 pts 1 ________ 10 pts 11 ________ /10 pts 21 ________ /10 pts 2 ________ 10 pts 12 ________ /10 pts 22 ________ /10 pts 3 ________ 10 pts 13 ________ /5 pts 23 ________ /10 pts 4 ________ 10 pts 14 ________ /5 pts 5 ________ 10 pts 15 ________ /5 pts 6 ________ 10 pts 16 ________ /5 pts 7 ________ 10 pts 17 ________ /5 pts 8 ________ 10 pts 18 ________ /10 pts 9 ________ 10 pts 19 ________ /10 pts 10 ________ 10 pts 20 ________ /5 pts 1Name: ____________________ UFID#: ______________________ Question 1: Select the correct statement(s) concerning a two-compartment body model. (10 pts) 1 For a two-compartment-body model drug, the parameter alpha is always larger than the parameter beta. 2 The volume of distribution during the beta phase is larger than that of the volume of distribution at steady state. 3 We often use one compartment model pharmacokinetics, although a number of drugs show a distinct distribution phase, especially if the higher concentrations during the alpha phase are not related to toxicity. 4 Assume that a low extraction drug, showing a two compartment model behavior is metabolized via enzymes that are subject to enzyme induction by other drugs. The volume of distribution during the beta phase might be decreased by such enzyme-inducers The correct statement(s) is (are): A: 1, 2, 3, 4 B: 2 and 3 C: 1 and 4 D: 1 and 3 E: 1, 2 and 3 2Name: ____________________ UFID#: ______________________ Question 2: Select from the following statements the correct statement(s) (10 pts) 1 The time to reach steady state is 4-5 half-lives, only when drugs are given as multiple short term infusions or multiple iv bolus injections. 2 The time to reach steady state is affected by the clearance and volume of distribution of the drug. 3 Drugs showing a high degree of accumulation will also need a long time to reach steady state (no loading dose is given) 4 For multiple short term infusions, the time to reach steady state depends on the dose. A: (1, 2, 3, 4) B: (1, 2, 4) C: (1, 3, 4) D: (2, 3) E: (2, 4) 3Name: ____________________ UFID#: ______________________ Question 3-6: The following applies to questions 3-6: A 60-kg patient is to be started on a continuous intravenous infusion. From a previous regimen of the same drug, you estimate the patient’s ke is 0.07 h-1 and the Vd is 40 L. Assume that none of this drug has been administered this month. Question 3: If the Cpss is to be 30mg/L, what would be the loading dose (mg) given as intravenous bolus injection? (10 pts) A 120 mg B 240 mg C 1200 mg D 1220 mg E 2400 mg 4Name: ____________________ UFID#: ______________________ The following applies to questions 3-6: A 60-kg patient is to be started on a continuous intravenous infusion. From a previous regimen of the same drug, you estimate the patient’s ke is 0.07 h-1 and the Vd is 40 L. Assume that none of this drug has been administered this month. Question 4: What rate of infusion (ko for the following constant rate infusion) should result in a Cpss of 30 mg/L (10 pts) A: 4.2 hr-1 B: 42 mg/ 0.5 hours C: 42 mg/hr D: 42 mg E: none of the above 5Name: ____________________ UFID#: ______________________ The following applies to questions 3-6: A 60-kg patient is to be started on a continuous intravenous infusion. From a previous regimen of the same drug, you estimate the patient’s ke is 0.07 h-1 and the Vd is 40 L. Assume that none of this drug has been administered this month. Question 5: What will be the plasma concentration 2 hours after start of the continuous infusion (remember this patient got a loading dose) (10 pts) A: 3.9 mg/L B : 4.0 mg/L C: 3.6 mg/L D: 30 mg/L E: None of the above. 6Name: ____________________ UFID#: ______________________ The following applies to questions 3-6: A 60-kg patient is to be started on a continuous intravenous infusion. From a previous regimen of the same drug, you estimate the patient’s ke is 0.07 h-1 and the Vd is 40 L. Assume that none of this drug has been administered this month. Question 6: The infusion is continued for 3 days and the steady state concentration has been maintained at 30 mg/L. The physician wants to change the drug delivery to multiple short term infusions with a Cmax of 30 mg/L and a trough of 15 mg/L How many hours after the stop of the continuous infusion should the first short-term infusion be given. (10 points) A: 1 h B: 2 h C: 6 h D: 20 h E: None of the above. 7Name: ____________________ UFID#: ______________________ The following pertains to Questions 7-8 A 60 kg patient is started on 80 mg of gentamycin, every 6 hr given as a one-hour infusion. Question 7: If this patient is assumed to have an “average” volume of distribution (value of the population mean) of 0.25 L/kg and a normal half–life of 3 hr, what would be the trough plasma concentration at steady state (Cmin value taken 1 hour before the start of the next infusion)? Please provide calculations. (10 points) A: 3.2 mg/L B: 2.5 mg/L C: 0.8 mg/L D: 1.2 mg/L E: None of the above 8Name: ____________________ UFID#: ______________________ A 60 kg patient is started on 80 mg of gentamycin, every 6 hr given as a one-hour infusion. Question 8: If the infusion is given the first time, how much lower is the first peak when compared to the Cmax at steady state (Cmax,ss).(10 points) A: 25% of Cmax,ss B: 50% of Cmax,ss C 75% of Cmax,ssD: 99% of E: Don’t have enough information to provide this information. 9Name: ____________________ UFID#: ______________________ Question 9: )'t(kkTkomineeeee1e1CLkCp•−τ•−∗−•−−•=Select the true statements concerning the following part of the equation: