PHA 5127 Dose Optimization I Case Study IV 1. For the following situations, indicate whether the drug is: filtered, reabsorbed (if fully or if reabsorbed through transporters), or actively secreted (Assume GFR is 130mL/min, urine flow is 1.5mL/min) a. Drug with fu= 0.3 and a Clren=39mL/min b. Drug with fu=0.6 and a Clren=30mL/min c. Drug with fu=0.05 and a Clren=15mL/min d. Drug with fu=0.2 and a Clren=0.3mL/min e. Drug with fu=0.8 and a Clren=0.3mL/min 2. A 25 year old, 5’6’’, 80kg male patient with a serum creatinine concentration of 1.8mg/dL was given a drug treatment. Knowing this drug is mainly eliminated by glomerula filtration and has 60% plasma protein binding. Please estimate the Clearance of this drug (with Cockcroft-Gault equation) 3. TRUE (T) or FALSE (F) For a high extraction drug, liver blood flow is important to both hepatic clearance and oral bioavailability. T F For low extraction drug, fu (fraction of unbound drug in plasma) is important to both hepatic clearance and oral bioavailability. T F Basic drugs that are polar in their unionized form, the extent of re-absorption depends on the degree of its ionization. T F Secretion is indicated when renal clearance is larger than GFR*fu. T FIt is possible for renal clearance to be close to the kidney blood flow. T F Assuming no plasma protein binding, the renal clearance equals the urine flow when full re-absorption occurs. T
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