Unformatted text preview:

Case Study 5 Dose Optimization – I (Fall 2010) PHA 5127 1) Identify the Pharmacokinetic metrics: Dose, Volume of Distribution or the Clearance (only pick one per scenario), whose changes would determine the differences observed in the following concentration time profiles. (eg: The structure of the answer would look like – The changes in the profiles of Fig A would be because of ____ parameter) Fig A Fig B Fig C Fig D Ans) Fig A – Dose; Fig B – Vd; Fig C – Clearance; Fig D – Dose2. List the assumptions that apply for a one compartment body model. (IV bolus administration). a) The Distribution is instantaneous b) Elimination is a first order process c) Linear Pharmacokinetics True or False: 1) For a drug characterized by a one compartment body model and administered as an IV bolus the expression AUC0-inf = Co/Ke can be used to calculate the AUC0-inf. (T/F) 2) CLtot = CLbil + CLren +CLmet is always true. (T/F) 3) In the equation ܥ =ቀ஽௢௦௘௏ௗቁ∗ ݁^(−݇݁ ∗ ݐ) , the expression ݁^(−݇݁ ∗ ݐ) has a value between o and 1.


View Full Document

UF PHA 5127 - Dose Optimization

Download Dose Optimization
Our administrator received your request to download this document. We will send you the file to your email shortly.
Loading Unlocking...
Login

Join to view Dose Optimization and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Dose Optimization 2 2 and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?