Case Study 5 Dose Optimization – I (Fall 2010) PHA 5127 1) Identify the Pharmacokinetic metrics: Dose, Volume of Distribution or the Clearance (only pick one per scenario), whose changes would determine the differences observed in the following concentration time profiles. (eg: The structure of the answer would look like – The changes in the profiles of Fig A would be because of ____ parameter) Fig A Fig B Fig C Fig D Ans) Fig A – Dose; Fig B – Vd; Fig C – Clearance; Fig D – Dose2. List the assumptions that apply for a one compartment body model. (IV bolus administration). a) The Distribution is instantaneous b) Elimination is a first order process c) Linear Pharmacokinetics True or False: 1) For a drug characterized by a one compartment body model and administered as an IV bolus the expression AUC0-inf = Co/Ke can be used to calculate the AUC0-inf. (T/F) 2) CLtot = CLbil + CLren +CLmet is always true. (T/F) 3) In the equation ܥ =ቀ௦ௗቁ∗ ݁^(−݇݁ ∗ ݐ) , the expression ݁^(−݇݁ ∗ ݐ) has a value between o and 1.
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