HNF 462 1st Edition Lecture 6Outline of Last Lecture I. Discoverya. PellagraII. Sources and Structuresa. Tryptophan and the LiverIII. Digestion, Absorption, and TransportationIV. In the CellsV. Degradation/ExcretionVI. Coenzyme FunctionsVII. Toxicity and Measurementa. RDAOutline of Current Lecture I. Food Sources and Digestiona. CoAII. Absorption, Transport, and ExcretionIII. FunctionsIV. Deficiency and Measurementsa. AICurrent Lecture: Pantothenic Acid1. Food Sources and Digestiona. Available in wide distribution of foods in the form of CoAb. CoA must be digested in order to be absorbed: process breaks three bonds of CoA2. Absorption, Transport, and Excretiona. Intestinal Absorptioni. By passive diffusion in high concentrationsii. By Na-dependent active transport in low concentrations1. Uses the SMVT transporter (also transports biotin and lipoic acid)These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.b. Cellular Absorption by Na-dependent active transport or facilitated diffusionc. Excreted intact through urine3. Functions: Essential because CoA is very importanta. Transfers acetyl/acyl groups (attach groups to the active –SH site)b. Substrate for many reactions (ex. TCA cycle) because contains high-energy bond that provides energy for the reactionsc. Coenzyme for: pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase, acetylation reactions of sugars/proteins, and synthesis reactions of FA/cholesterol/ketones/steroid hormones4. Deficiency and Measurementsa. Deficiency rare b. Burning Feet Syndrome, vomiting, and fatiguec. Associates with other deficiencies d. Measured by microbiological growth curves, HPLC, and radioimmunoassaye. AI = 5 mg/day i. No
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