CHAPTER TEN AEROBIC METABOLISM II 1 Molecules involved in the conversion of oxidized proteins to their functional reduced suylfhydryl form include all of the following except 2 All of the following are components of the electron transport chain except 3 The ETC component that transfers electrons directly to oxygen is 4 During the oxidation of NADH there are several steps in which Eo is sufficient for ATP synthesis These occur within Thioredoxin B NADPH C Catalase D Thioredoxin reductase E None of the above are correct Ans C A Coenzyme Q B Succinate dehydrogenase C Coenzyme A D Cytochrome c E NADH dehydrogenase Ans C A Cyt c B UQ C Cyt bc1 D Cytochrome oxidase E Succinate dehydrogenase Ans D A Complexes I II and III B Complexes I III and IV C Complexes II III and IV D Complexes III IV and V E Complexes I II and IV Ans B 5 Which of the following molecules inhibits Complex I of the electron transport chain A Azide B Amytal C Cyanide D Arsenic E Carbon monoxide Ans B A Protonmotive force B High energy intermediates C Proton gradient D Both A and C are correct E All of the above are correct Ans D 6 ATP synthesis and mitochondrial electron transport are coupled by 7 Evidence supporting the chemiosmotic theory inculdes all of the following except A Inhibitors of ATP synthesis have been shown to dissipate the proton gradient B Mitochondria with disrupted membranes cannot synthesize ATP C ATP synthesis is depressed when mitochondrial swelling occurs as a result of osmotic changes D The pH of a weakly buffered suspension of mitochondria rises when O2 added E Actively respiring mitrochondria expel protons Ans D 8 Examples of uncouplers include A DNP B Antimycin C Gramicidin D Both A and B are correct E Both A and C are correct Ans E 9 In the ATP Synthase the Fo factor A Has three types of subunits B Possesses ATPase activity C In a transmembrane proton channel D Both A and B are correct E Both A and C are correct 10 The maximum P O ration of FADH2 is Ans E A 1 5 B 1 75 C 2 0 D 2 5 E 3 0 Ans A A HPO4 2 B NADH C FADH2 D Citrate E ADP Ans E 12 The first ROS formed during the reduction of oxygen is A Hydrogen peroxide B Hydroxyl radical C Singlet oxygen D Superoxide radical E None of the above are correct Ans D 11 The control of aerobic respiration by is referred to as respiratory control 13 The reaction of Fe 2 with H2O2 results in the production of A Hydroxyl radical B Hydroxide ion C Superoxide radical D Both A and B are correct E Both A and C are correct Ans D 14 ROS are generated during A Xenobiotic metabolism B Respiratory burst C Ionizing radiation D Both A and B are correct E All of the above are correct Ans E 15 Glutathione peroxidase A Converts organic peroxides into alcohols B Generates GSH from GSSG C Reduces H2O2 into H2O D Both A and B are correct E Both A and C are correct Ans E Ans A A The pentose phosphate pathway B Glycolysis C The citric acid cycle D Both A and B are correct E Both A and C are correct 16 The NADPH required for the generation of GSH from GSSG in synthesized by the reactions of 17 Glutathione peroxidase requires for full activity A Sulfur B Copper C Iron D Selenium E Magnesium Ans D 18 Examples of antioxidants include all of the following except A Ascorbic acid B Carotene C Tocopherol D Hydroquinone E Gramicidin 19 One of the mechanisms by which vitamin C protects membrane is by Ans E Ans E A Regenerating reduced tocopherol B Reacting with proline C Reacting with peroxyl radicals D Both A and B are correct E Both A and C are correct 20 The ultimate electron acceptor of the mitochondrial electron transport system is A Coenzyme Q B NADPH C O2 D H2O E Both C and D are correct Ans C 21 The major sources of NADH that reduce Complex I of the ETC include A Fatty acid oxidation B CoQ C Pentose phosphate pathway D The citric acid cycle E Both A and D are correct Ans E 22 In Complex III electrons are tranferred from UQH2 to A O2 B Coenzyme Q C Cytochrome c D FAD E NADH Ans C A Fe B S C Co D Zn E Ca Ans A 23 is a metal cofactor of the cytochromes 24 Carbon monoxide inhibits which of the following A NADH dehydrogenase B Ubiquinone C Cytochrome oxidase D Succinate dehydrogenase E None of above are correct Ans C 25 Which of the following is the best reducing agent 26 The final product of oxidative phosphorylation is A H2O B O2 C FADH2 D FMNH2 E NADH Ans E A Water B ADP C NADPH D ATP E FMNH2 Ans D A Uncouplers B Ionophores C Xenobiotics D Radicals E None of the above are correct Ans B A Ca 2 cAMP B Fe 2 CoQ C ADP NADH D ADP CoASH E H ATP Ans E 27 are hydrophobic molecules that dissipate ionic gradients 28 The return of into the mitochondrion is coupled to the formation of 30 Reducing power generated in the cytoplasm can be transferred into the mitochondrion by which of the following processes 29 The energy that is captured by the electron transport system is in the form of A NADH B FADH2 C ATP D Both A and B are correct E All of the above are correct Ans D A Glycerol phosphate shuttle B Malate aspartate shuttle C The phosphate shuttle D A and B are correct E All of the above are correct Ans D A FADH B Heme C TPP D Zinc E NAD Ans B A Coenzyme Q to Cyt c B NADH to CoQ C Succinate to UQ D CoQ to NADH E UQ to succinate Ans A 31 The cytochromes contain which type of prosthetic group 32 The function of complex III is the transfer of electrons from 33 Which of the following complexes contain copper 34 Which of the following acts as an allosteric inhibitor of complex IV 35 Which of the following is not a step in the ATP synthesizing process A ADP Pi bind to the L site B ATP is synthesized as the L conformation converts to the T conformation C ATP is released as the T conformation converts to the O confirmation D The O conformation binds ADP and Pi E All of the above are correct 36 Nonshivering thermogenesis is regulated by which of the following A Complex I B Complex II C Complex III D Complex IV E Complex V Ans D A FMN B NADH C FADH2 D ATP E ADP Ans D Ans D A Norepinephrine B Thermogenin C UCP2 D ATP E GTP Ans A 38 How many ATP are generated during the oxidation of one NADH 39 Which of …