Which of the following statements about PSPs is FALSE?When during the action potential is PNa:PK the greatest?Slide 3Slide 4Slide 5Reversal PotentialThe reversal potential of NMDA receptors would change if….What would happen if a synapse only contained NMDA receptors?Slide 9SummaryWhich of the following statements about PSPs is FALSE?A. Generated by the activity of synapses.B. Maintain the same amplitude as they travel.C. Sum togetherD. Responsible for the generation of an action potential.When during the action potential is PNa:PK the greatest?1. A2. B3. C4. DABCDIs the rate of axoplasmic transport influenced by the rate of action potential propagation?A. YesB. NoAmino Acids Amines PeptidesSynthesisStorageReleaseReceptorsEliminationReversal PotentialV (mV)I (pA)The reversal potential of NMDA receptors would change if….A. The channel is closed B. The concentration of extracellular potassium increased C. The membrane were depolarized D. There was no magnesium extracellularlyWhat would happen if a synapse only contained NMDA receptors?A. There would be no EPSP in response to glutamate release B. The EPSP would be larger in response to glutamate releaseC. LTP could be induced more easily than normal D. LTP could not be inducedIf a mutation in a Gα protein causes it to hydrolyze GTP faster than normal, what effect would this have on signaling?A. The signal would last longerB. The signal would be shorterC. The signal would last the same length of time but would not be as amplifiedD. There would be no effect on signalingSummary•PSPs occur at synapses and sum as they travel to the axon hillock–Excitatory or inhibitory depending on the reversal potential of the receptor–Decay as travel•Action potential initiated at axon hillock when threshold is reached–V-gated Na channel opening, inactivation of v-gated Na channels and opening of v-gated K channels, deinactivation of v-gated Na channels and closing of v-gated K channels–Conduction down the axon moves unidirectionally due to the refractory period, speed of conduction depends on the diameter of the axon, the resistance of the membrane, and the myelination state–Regenerate as travel•When an action potential reaches the axon terminal open v-gated Ca channels and vesicles are released–SNARE proteins tether vesicles to presynaptic membrane and trigger fusion when Ca enters the terminal–Neurotransmitters are loaded into vesicles either in the axon terminal by vesicular transporters (small molecule NTs) or by their production in the cell body and transport down to the axon terminal in vesicles (peptides)•Receptors are activated and either generate a PSP (ionotropic) or signal intracellularly (metabotropic)•Signal is terminated by either diffusion, degradation, or