Synaptic PlasticitySlide 2Slide 3AMPA ReceptorsNMDA ReceptorsSlide 6NMDA glutamate receptorSlide 8What would happen if a synapse only contained NMDA receptors?Slide 10SummarySynaptic Plasticity•What is Long Term Potentiation? What are the molecular mechanisms underlying LTP?•What is Long Term Depression?NMDA- dependent Long Term PotentiationNeurons that fire together wire together.AMPA- and NMDA-glutamate receptors coexist at many glutamatergic synapsesAMPA ReceptorsNMDA ReceptorsIf a single EPSP is not enough to remove the Mg2+ block from NMDA receptors, what needs to occur?A. An action potentialB. SummationC. An IPSPD. ShuntingE. The dendrite need to be widerNMDA glutamate receptorneuron depolarized A MOLECULAR “COINCIDENCE DETECTOR” Mg2+neuron not depolarized enough Mg2+Molecular Mechanisms of Long Term Potentiation (LTP)Neurons that fire together wire together.CREBWhat would happen if a synapse only contained NMDA receptors?A. There would be no EPSP in response to glutamate release B. The EPSP would be larger in response to glutamate releaseC. LTP could be induced more easily than normal D. LTP could not be inducedNMDA- dependent Long Term DepressionNeurons that fire out of sync lose their link.Summary•LTP strengthens synapses and is thought to underlie the formation of some new memories–Requires the activation NMDA receptors•Coincidence detectors- glutamate and depolarization•Activates CREB and enhances the number of AMPA receptors•LTD weakens synapses by reducing the number of AMPA
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