Neurotransmitter ReceptorsSlide 2Metabotropic G-Protein-Coupled ReceptorsSlide 4Effector ProteinsSlide 6Slide 7SummaryNeurotransmitter Receptors•What do ionotropic and metabotropic receptors look like?•How do metabotropic G-protein-coupled receptors signal?Ionotropic Receptors(Ligand-Gated Receptors)Metabotropic G-Protein-Coupled ReceptorsG-Protein SignalingEffector ProteinsIf a mutation in a Gα protein causes it to hydrolyze GTP faster than normal, what effect would this have on signaling? A. The signal would last longerB. The signal would be shorterC. The signal would last the same length of time but would not be as amplifiedD. There would be no effect on signaling.Summary•Most ionotropic receptors are made from 5 subunits, each of which have 4 transmembrane domains•Metabotropic G-protein coupled receptors are made from one large 7 transmembrane protein–Many subtypes of G-proteins–G-protein signaling can work directly on channels, but more often their work through other effector proteins, such as kinases and phosphotases.–More than 1 G-protein is activated upon NT binding, which leads to a large amplification of the
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