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Penn BIBB 109 - 11-2-12 Audition- Signal Transduction

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Audition- Signal TransductionI. What is sound?Slide 3Audition- Signal TransductionStructure of the earCochleaSlide 7Do you think that the apex vibrates more in response to:Slide 9Audition- Signal TransductionSlide 11Slide 12Slide 13What would happen if the tip links were cleaved (cut)?Outer hair cells work mostly as amplifiersSummaryAudition- Signal Transduction•What is sound?•How does sound move through the ear?•How is the movement of sound through the ear converted into a neuronal signal?I. What is sound?Pitch-Loudness/Intensity-Audition- Signal Transduction•What is sound?•How does sound move through the ear?•How is the movement of sound through the ear converted into a neuronal signal?Structure of the earCochleaDo you think that the apex vibrates more in response to:a) Low frequency soundsb) High frequency soundsc) Equally to all frequency soundsCountdown10Audition- Signal Transduction•What is sound?•How does sound move through the ear?•How is the movement of sound through the ear converted into a neuronal signal?Signal TransductionMembrane DepolarizationTimeWhat would happen if the tip links were cleaved (cut)?a) Hair cells would be less depolarized when the basal membrane descendsb) Hair cells would be more depolarized when the basal membrane descendsc) Hair cells would not depolarize when the basal membrane descendsCountdown10Outer hair cells work mostly as amplifiersSummary•Sound is a wave of alternating compressed air and rarified air•Sound enters the outer ear, vibrates the tympanic membrane, which vibrates the ossicles in the middle ear, and then the ossicles vibrate the fluid in the inner ear, which causes the basilar membrane to vibrate•Vibration of the basilar membrane is converted to a neuronal signal when the stereocilia of hair cells in the Organ of Corti (on the basilar membrane) are bent, allowing potassium to flow in and depolarizing the hair cells–Inner hair cells are mostly responsible for signal transduction–Outer hair cells are mostly responsible for signal


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Penn BIBB 109 - 11-2-12 Audition- Signal Transduction

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