PHYSIOLOGY4521552 FINAL EXAMINATION Thursday May l 2003 3 30 6 30P M INSTRUCTIONS Pleasemarkyour 4g1qgand8 digitUB personnumberclearlyon theanswersheet Fill in the correspondingcircleson the answersheet Pleasemark your answerscarefullyon the answersheetwith a 2 pencil IMPORTANT NOTE IF YOU ERASE PLEASEDO SO COMPLETELY Thereis only one bestanswerfor eachquestion This examconsistsoflq multiple choicequestions All questions readthequestions carefully carryequalweight Please You may keepthe examination for study Answerswill bepostedacrosslhe hall from afterthe exam Be sureto makea list of your r ooml ShermanHall imraediately answersbeforeleavingtheexamroomsothatyou cangradeyourselfon this exam Ifyou believethata questionis ambiguous or incorrectlykeyed pleasesubmityour commentson the Main Office 124ShermanHall bv 12 00n m FRIDAY MAY 2 2003 INSTRUCTORSWILL NOT ANWER QUESTIONSDURING THE EXAM CHEATING ON EXAMS In an effort to decreasethe temptation to cheat on hourly and final examswe ask that you follow the procedures listedbelow l 2 3 4 5 Keep your answersheetcoveredexceptwhen addingan answer to checkagainstthe key please When creatingyour own list of zmswers write small and be asdiscreteas possible Pleaseinform one ofthe instructorsas soonas possibleifyou suspect someoneis cheating Your commentswill be kept confidential Rememberthat accordingto University policy a personqivinq ansrvetsts equally as guilty as a personggggly 1ganswers The ultimatepenaltyfor cheatingis dismissalfrom the University Choosethe one BEST answerfor questionsI 9 l Which oneofthe following would no1be involved in the cardiacpacemakerresponseto acetylcholine a inhibition of Ir turny curent b hyperpolarizationofthe cell membrane c decreasedrateofdiastolic depoladzation d inhibitionofl type calciumchannels 2 Thelength tension relation oftheheart Q r a is deFesseddudng heartfailue b increasesthe cardiacoutputafter adjustingto the upright position c allows the Ieff heartoutputto exceedth dght heartoutput d inqeasesstrokevolumeimmediatelyafler arterialpressue is elevated 3 Which oneofthe following is Dot associaledwith reactivehyperemia a vasodilationcausedby releaseof norepinepbrinefrom sympatheticnerves b aacwnulationof vasodilatorproductsof metabolism c myogenicrelaxationof arteriolarsmoothmuscle d ischemia 4 Which oneofthe following would not b associatedwith flow mediatedvasodilation a increasedmechanicalshearstresson endothelialcells b stimulalionofendothelial nitric oxide synlhase eNOS c increasedcyclic GMP Jl t plasma d inoeased levelsofangiotensin II 5 Applicationof digitalis cardiacglycoside to cardiacmuscle a accelerates therateofNa Ca 2 exchangein the sarcolemma b reducesmaximumforcedevelopment c depresses the sarcolemmalNa I pump t c t t d decreases myocardialoxygenconsumption 6 Padial local reductionofthe radiusofan artery supplyinga metabolicallyactivetissue by 30 stenosis dueto an atherosclerotic plaqueis associared with a nearnormalblood flow at rest becauseof autoregulationin the arteriolesdownsaeam from the plaque b reducedactivehypercmiain the tissue c decreasedarterialpressurein the arterial downstreamfrom the stenosis d all ofthe above t t1 7 Which of the following conditionswould not developasthe resultofdamageto the capillary membfane a increasedcapillaryreabsorption b increasedlymph flow c increasedcapillaryfiltation d increasedinterstitialfluid pressure 8 Ifarterial bloodpressurew re doubledat the sametime that the p lipheralresistancewas reducedby hall theblood flow throughan anery would be a doubled b halved c 16times greater d 1 16asmuch 9 Whena persondsesquickly to the upright position ftom a supineposition a carotidsinusnerveactivity increases b venousrctumto the heartis iDcreased c reflex vasoconstrictionof peripheralarteriolesoccurs d heartrate deqeases Usethe following codefor questionsI 0 through I 5 a item in Column I is greaterthan the item in Column 2 b item in Colu n I is lessthan the item in Column 2 c item in Column I is equalto or the sameasthe item in Column 2 ColumnI Column2 1 0 Permeability ofbraincapilla es 1 1 Volumeofnormaltissue Volumeoftissuewith lymphatics obstructed L 12 Cerebralvenouspressure in rhesupine posiLion Permeability of liver capillades I Cerebralvenouspressurein the standing uprightposition 1 3 Velocityofbloodflow in themicrocirculation 7 Velocityofblood flow in theaorta 1 4 Gastroinlestinalblood flow during digestion Gastrointestinalblood flow during the hypothalamicdefensereaction 15 Tissuevolumeofrestingmuscle Tissuevolume of rhythmically contacting muscle 1 For questionsl6 22 we answer A if the ntirest4teme is TRUE and B if any Dan ofthe sratement is FAISE 16 Stimulationofthe 82 receptorcon air aysmoothmusclewill causea decreasein airway resistance t 7 Activation ofthe abdominalmuscleswill causeexpirationby pulling the diaphragnrdownward 18 FRC in an individual with pulmonaryfibrosiswill be lessthannormal 19 During inspirationin a normal individual morework is requiredto overcome lung elasticfibers than surfacetension 20 The volumeof the alveolar deadspacewill incr as in an individual with a pulmonaryembolism 2t I f a normalindividual movesAom the standingpositionto lying down the V t Q ratio will decrease 22 The driving pressue pressuredifference for the flow of oxygenacrossthe alveolar capillaryrnembraneis equalto the driving pressurefor carbon dioxide Choosethe ONE BEST answerfor questions23 30 23 In which ofthe following diseaseswill lung compliancedecrease a b c d e 24 respiratorydistess q ndromeofthe newbom RDS pulmonaryfibrosis any diseasein which the function ofthe alveolarlpe 2 cells is depressed onlya baretrue 4 b ca re tu e The diffusing capacityofthe lung a b c d decreasesduring exercise rnoeasesin a personwith emphysema increasesif the lhicknessof the alveolar capillarymembranedecreases onlya baretrue a b ca re tru e 25 In a penon with emphysema a b c d 26 pulmonaryvascularresistancedeoeases the numberofpulmonary capillariesincreases lung compliancedeueases hypoxicpulmonaryvasocolstliclion may occur all ofthe abovearetrue Which ofthe following statementsis FALSE a In an anemicpersonwith normalhemoglobin the oxygensaturationof the arterialblood will be normal b The hematocritofa normalindividual who movesto high altitude 10 000 feet for 2 monthsmay increase c In a penon with anemiathe alveolarventilation will be Inuchgreaterthan normal d During maximalexercisein a normalindividual the Cao2may increase15 fold tines e In