PHYSIOLOGY 452 552 FINAL EXAMINATION Thursday May 3 2007 INSTRUCTIONS This examination consists of 80 multiple choice questions Please print your name and 8 digit UB person number clearly on the answer sheet and exam Fill in corresponding circles on the answer sheet Please mark your answers carefully on the answer sheet with a 2 pencil If you erase do so completely There is only one best answer for each question This exam consists of 14 pages including this cover page and 80 questions Please check that your copy has all pages All questions carry equal weight read the questions carefully Answers will be posted as soon as possible on UBLearns TURN OFF ALL CELL PHONES ANYONE WHO ANSWERS A CELL PHONE DURING THE EXAM WILL RECEIVE A ZERO 0 FOR THE EXAM CHEATING ON EXAMS In an effort to decrease the temptation to cheat on hourly and final exams we ask that you follow the procedures listed below 1 2 3 4 5 Keep your answer sheet covered except when adding an answer When creating your own list of answers to check against the key please write small and be as discrete as possible Please inform one of the instructors as soon as possible if you suspect someone is cheating Your comments will be kept confidential Remember that according to University policy a person giving answers is equally as guilty as a person receiving answers The ultimate penalty for cheating is dismissal from the University The version of YOUR exam is VERSION 1 On side two of your answer sheet scantron there is a Grade or Education box below the Identification box where you add your student number In this Grade or Education box fill in circle 1 If you do not add your exam version you will receive a zero 0 for this exam If you fill in the WRONG number you will be scored for the number you fill in This is your responsibility only If you fill in the wrong number it cannot be changed after you turn in your exam 1 Which of the following is NOT true of calcium a b c d e It inhibits protein kinase C It is stored primarily in bone High concentrations in the blood result in increased 24 25 OH D3 synthesis It is released from intercellular stores by the actions of Gq coupled receptors Release of intercellular stores usually stimulates peptide hormone secretion 2 Which of the following is NOT synthesized in the adrenal gland a b c d e Aldosterone Androgens Cortisol Estrogens None of the above 3 If a fetus has not expressed testes determining factor TDF by the 9th week of gestation a b c d e it will develop as a female the Wolffian duct will develop into ovaries and other female specific organs it will not express androgens it will develop gonadal dysgenesis All of the above 4 What property is shared by Sertoli cells follicular granulosa cells a b c d e The presence of aromatase The presence of FSH receptors They secrete inhibin A B only All of the above 5 Thyroid hormone and cortisol exert their major effects through which of the following a b c d e Transcription Tyrosine kinase DNA replication Translation None of the above 6 One month after gestation a fetus could be called indifferent because a b c d e it lacks the SRY gene it has an XXY genotype it has no gender phenotype it secretes anti m llerian hormone sigh it just doesn t care anymore 2 7 Why is progesterone sometimes called an anti estrogen a In the endometrium it inhibits transcription while estradiol E2 stimulates transcription b Because when blood progesterone levels are high estrogens are low and vice versa c It stimulates the conversion of estradiol E2 to the much less potent estrone E1 d It stimulates release of LH luteinizing hormone and FSH follicle stimulating hormone from the pituitary while estrogens inhibit LH FSH release e All of the above 8 What happens to the circulating concentrations of the following hormones immediately preceding the recruitment of a cohort of follicles a b c d e Both estrogens and progesterone decrease Inhibin increases and estradiol E2 decreases FSH follicle stimulating hormone increases and inhibin decreases Both LH luteinizing hormone and estrogens increase None of the above 9 Aldosterone is considered a mineral corticoid because a b c d e its primary tissue target is the kidney it is a steroid it is synthesized in the adrenal gland it promotes uptake of calcium from the gastrointestinal tract it contains iodine 10 Which of the following is NOT true of gonadotropin releasing hormone GnRH a b c d e It is expressed in both males and females Its release is pulsatile in both males and females It is absent until puberty There is a surge in blood levels prior to ovulation It is secreted from neurons in the hypothalamus 11 Which of the following hormones has the shortest half life t in the bloodstream a b c d e Parathyroid hormone PTH Epinephrine Insulin Thyroid hormone T4 Cortisol 3 12 Which of the following hormones are secreted from the anterior pituitary a Thyroid releasing hormone TRH adrenocorticotropic hormone ACTH and growth hormone GH b Thyroid stimulating hormone TSH luteinizing hormone LH and growth hormone GH c Insulin like growth factor 1 IGF1 glucagon and parathyroid hormone PTH d Chorionic gonadotropin CG prolactin and thyroid releasing hormone TRH e Corticotropin releasing hormone CRH follicle stimulating hormone FSH and antidiuretic hormone ADH 13 Glycogen is to triglycerides as glucose is to a b c d e insulin protein free fatty acids glucagon glycerol 14 Which of the following hormones is synthesized from a cholesterol precursor a b c d e Insulin like Growth Factor 1 IGF1 Epinephrine 1 25 OH 2D3 Leptin Calcitonin 15 Which of the following statements is true Testosterone a b c d e inhibits synthesis of estrogens in Sertoli cells is not synthesized in females is a precursor of glucocorticoids is converted to DHT in target tissues All of the above 16 Which of the following is NOT true of gap junctions in cardiac muscle a Pairs of hemichannels assemble to form functional communication between cells b Gap junctions are non selective large pore channels A Large multi nucleated array of myofibrils essentially one large fused cell c Have a voltage sensor on the S4 alpha helix of each tetramer d Facilitate electrical communication between cells e None of the above 4 17 The sarcoplasmic reticulum is a b c d e The basic contractile unit in skeletal muscle Equivalent to the cell membrane which covers the entire fiber Contains a calcium transporting ATPase pump A specialized intracellular structure that regulates sodium None of the