BIOB 375 1st Edition Lecture 37 Outline of Last Lecture II. Population Genetics IIOutline of Current Lecture III. ReviewCurrent LectureGenetics: is the science of heredity and variation in living organismsBe able to describe the genetic material in two major types of organisms:- Where does each genetic material locate?- How are each of the genetic materials arranged or packed in a cell?- How are each of the genetic materials inherited?Basic chromosome structures for bacteria and eukaryote- Bacteriao Origin of replication- Eukaryoteo Origin of replicationo Centromereo TelomereAble to describe the mechanisms for inheritance:- Accurately replicating- Equally dividing- DNA repairing- Check points to prevent DNA damages Able to describe the sources of genetic variation- Asexually reproducedo Mutation Base substitutions/indels Chromosome mutations Transposition of TEs- Sexually reproducedo Mutation Base substitutions/indels Chromosome mutations Transposition of TEso Chromosome reassortmento Recombination Able to recognize types of mutations Able to design molecular markers to distinguish two different phenotypes based on given DNA sequenceTo identify the type of mutation, always compare to the original chromosomeConcepts of insertion/deletion, transposition or TEs, and chromosome duplication/deletionInsertion/deletion - < 10,000 bpTransposition – footprints of direct repeatsChromosome duplication/deletion – large segment, > 10,000 bpBe able to distinguish genotype and phenotypeBe able to distinguish and describe sequences of DNA, RNA, and
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