ANSC 210 1st Edition Lecture 29Outline of Previous Lecture Outline of Current LectureI. Mouse ModelsII. Cystic FibrosisIII. Severe Combined Immune Deficiency or Nude MiceIV. Colon CancerV. Spinal Cord Injury VI. Feline Acquired Immunodeficiency SyndromeVII. Estrogen and Brain FunctionVIII. Ing Laboratory StudiesIX. Multiple Sclerosis Current LectureI. Mouse Modelsa. Jackson Laboratory b. Bar Harbor, MaineII. Cystic Fibrosisa. Lung disease in children b. Mutation in CFTR causes inability to clear infection with pseudomonasc. CFTR mouse has similar diseased. New drugs and gene therapies are being produced III. Severe Combined Immune Deficiency or Nude Micea. Mice without an immune systemb. They must be kept in a cage that is infection-freec. Can receive transplantsd. Good for studying skin graftse. Can transfer human pancreatic tumori. Studies how it spreadsii. Studies now it metastasizesIV. Colon Cancera. Fat and fiber contribute to development of colon cancerb. Inflammation is also involvedc. Drs. Chaplin and Lupton research nutritional prevention of colon cancer using ratsThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.d. Benefits of omega-3 fatty acids (fish oil) and fiber in the dietV. Spinal Cord Injury a. 450,000 people live with spinal cord injuries in USb. 10,000 new cases each yearc. Quadriplegia is more common than paraplegia d. Usually the nerve cells that are damagede. Some scientists are studying spinal cord injuriesf. Develop stem cells to regenerate nervesg. TAMU faculty consisting of:i. Psychology ii. Medical anatomy iii. Animal scienceiv. Veterinary v. Integrative biosciencesvi. Discovered a class of drugs for spinal cord recoveryVI. Feline Acquired Immunodeficiency Syndromea. Similar to AIDS in humansb. Causes similar diseasec. Currently used as an AIDS model to develop vaccination and treatmentd. Dr. Collison studied this in Veterinary Pathophysiology VII. Estrogen and Brain Functiona. Protects against ischemic insults - heart attacks and strokesb. Men have fairly consistent influence of tissue estrogenc. Postmenopausal women have little estrogen and are more at risk because they do not have any estrogen at alld. Estrogen protects against strokesVIII. Ing Laboratory Studiesa. If you give stallions glucocorticoids (stress hormones) decreases testosterone within hoursb. Castrated the stallions after 12 hoursc. Determined that 13 genes were altered due to the stress hormonesd. Causes lower testosterone levelse. Lower testosterone levels have decreases spermatogenesis IX. Multiple Sclerosisa. Demyelinating disease in peopleb. Can have relapsing or progressive diseasec. Autoimmuned. More prevalent in people who go to collegee. Mouse model - caused by Theiler's virus which causes Theiler's disease f. Dog model - degenerative myelopathy i. Can have relapses and then become fineii. The dog will become ataxic iii. This starts at the rear legs and works its way forwardiv. Prevalent in German
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