ANSC 210 1st Edition Lecture 29 Outline of Previous Lecture Outline of Current Lecture I II III IV V VI VII VIII IX Mouse Models Cystic Fibrosis Severe Combined Immune Deficiency or Nude Mice Colon Cancer Spinal Cord Injury Feline Acquired Immunodeficiency Syndrome Estrogen and Brain Function Ing Laboratory Studies Multiple Sclerosis Current Lecture I II III IV Mouse Models a Jackson Laboratory b Bar Harbor Maine Cystic Fibrosis a Lung disease in children b Mutation in CFTR causes inability to clear infection with pseudomonas c CFTR mouse has similar disease d New drugs and gene therapies are being produced Severe Combined Immune Deficiency or Nude Mice a Mice without an immune system b They must be kept in a cage that is infection free c Can receive transplants d Good for studying skin grafts e Can transfer human pancreatic tumor i Studies how it spreads ii Studies now it metastasizes Colon Cancer a Fat and fiber contribute to development of colon cancer b Inflammation is also involved c Drs Chaplin and Lupton research nutritional prevention of colon cancer using rats These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute V VI VII VIII IX d Benefits of omega 3 fatty acids fish oil and fiber in the diet Spinal Cord Injury a 450 000 people live with spinal cord injuries in US b 10 000 new cases each year c Quadriplegia is more common than paraplegia d Usually the nerve cells that are damaged e Some scientists are studying spinal cord injuries f Develop stem cells to regenerate nerves g TAMU faculty consisting of i Psychology ii Medical anatomy iii Animal science iv Veterinary v Integrative biosciences vi Discovered a class of drugs for spinal cord recovery Feline Acquired Immunodeficiency Syndrome a Similar to AIDS in humans b Causes similar disease c Currently used as an AIDS model to develop vaccination and treatment d Dr Collison studied this in Veterinary Pathophysiology Estrogen and Brain Function a Protects against ischemic insults heart attacks and strokes b Men have fairly consistent influence of tissue estrogen c Postmenopausal women have little estrogen and are more at risk because they do not have any estrogen at all d Estrogen protects against strokes Ing Laboratory Studies a If you give stallions glucocorticoids stress hormones decreases testosterone within hours b Castrated the stallions after 12 hours c Determined that 13 genes were altered due to the stress hormones d Causes lower testosterone levels e Lower testosterone levels have decreases spermatogenesis Multiple Sclerosis a Demyelinating disease in people b Can have relapsing or progressive disease c Autoimmune d More prevalent in people who go to college e Mouse model caused by Theiler s virus which causes Theiler s disease f Dog model degenerative myelopathy i Can have relapses and then become fine ii The dog will become ataxic iii This starts at the rear legs and works its way forward iv Prevalent in German Shepherds
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