UNT BIOL 3510 - Final Exam Study Guide (5 pages)

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Final Exam Study Guide

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Final Exam Study Guide


Covering lectures 22 through 26 for Exam 4 of BIOL 3510.

Study Guide
University of North Texas
Biol 3510 - Cell Biology

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BIOL 3510 1st Edition Exam 4 Study Guide Lectures 22 26 Lecture 22 November 18 Roles of Actin Networks include A Stable microvilli B Stable contractile bundles C Temporary protrusions needed for cell movement D Temporary cytokinetic contractile ring Microfilaments actin filaments are composed of globular actin proteins aligned into two twisted protofilaments Like MTs microfilaments have a distinct polarity Actin is more likely to be added to the plus end Microfilament MF Growth and Disassembly Actin is an ATPase Actin ATP is added to both ends faster growth at plus end After incorporation to a MF ATP is hydrolyzed to ADP causing a conformation change that destabilizes the MF Treadmilling and dynamic instability are dependent on nucleotide hydrolysis Some microfilaments are nucleated from actin nucleating proteins near the plasma membrane Microfilament behavior is modified by actin binding proteins Actin in action the three steps of cell crawling are actin dependent 1 Actin polymerization at the leading edge of the cell results in the protrusion of lemellipodia and filopodia Branched actin networks in lemellipodia are nucleated by ARP complexes Growth of unbranched microfilaments in filopodia and other structures is promoted by formins Formins promote the addition of actin monomers 2 Integrins bind to the extracellular proteins and internal microfilaments Integrins transmembrane proteins that interact with the crawling cell s environment connected to actin filaments 3 Internal contraction of the cell is mediated by myosin II an actin dependent motor protein All actin dependant motor proteins belong to the myosin family plus end directed two main types myosin I and myosin II bind and hydrolyze ATP Different myosin I proteins bind to different cell components Actin in action How does a cell know what type of microfilament network to form Cell signals converge on a family of Rho GTP binding proteins GTPases Rho promotes contractile bundles Rac promotes lamellipodia

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