UNT BIOL 3510 - Cell Cycle I (3 pages)

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Cell Cycle I

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Cell Cycle I


Lecture 23 covering from intro to cell cycle to prometaphase

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University of North Texas
Biol 3510 - Cell Biology

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BIOL 3510 1st Edition Lecture 23 Outline of Last Lecture I Roles of Actin Networks II Microfilament Growth and Disassembly III Actin in Action IV Resting and Contracting Muscle Cells Outline of Current Lecture I Intro to Cell Cycle II G1 Phase III Control of S Phase IV Prophase V Prometaphase Current Lecture Cell cycle duplication and division of a cell and its contents The cell cycle has four phases 1 2 3 4 G1 phase Gap Cell growth S phase synthesis DNA replication G2 phase Gap Cell growth M phase mitosis and cytokinesis Progress through the cell cycle controlled by the cell cycle control system Cyclin dependant kinases Cdks are major components of the cell cycle control system Cdk kinase that activates cell machinery constant amount cyclical activation Cyclin activates a Cdk cyclical amounts Cyclin concentrations are regulated by transcription and proteolysis Transcription gradual increase in cyclins Proteolysis quick decrease in cyclins APC anaphase promoting complex These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute In addition to cyclins Cdks are regulated by phosphorylation dephosphorylation and inhibitory proteins Different Cdk cyclin combos trigger different cell cycle events G1 Phase At the end of M all S Cdks and M Cdks are inactivated by cyclin degradation and inhibitor protein activation In mammalian cells mitogens promote cyclin transcription needed for entry into S phase Mitogens promote cell division by activating G1 Cdk and G1 S Cdks which inactivate Retinoblastoma Rb proteins Cell cycle progression is paused if the DNA is damaged or incompletely replicated 1 Inactivation of G1 S and S Cdks during G1 and S by p53 activation pauses the cell cycle o DNA repair or cell death o No p53 leads to the replication of damaged DNA promoting cancer Centrosome cycle centrosome duplication initiated in G1 is triggered by G1 S Cdk and S Cdk Control of S phase

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