UNT BIOL 3510 - Cellular Structure II (2 pages)

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Cellular Structure II

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Cellular Structure II


Covering Lecture 22 of BIOL 3510 from roles of actin networks to muscle cells

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University of North Texas
Biol 3510 - Cell Biology

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BIOL 3510 1st Edition Lecture 22 Outline of Last Lecture I Three Main Cytoskeletal Filaments II Roles of Microtubules in a Cell III Microtubule Growth and Disassembly IV Motor Proteins Outline of Current Lecture I Roles of Actin Networks II Microfilament Growth and Disassembly III Actin in Action IV Resting and Contracting Muscle Cells Current Lecture Roles of Actin Networks A B C D Stable microvilli Stable contractile bundles Temporary protrusions needed for cell movement Temporary cytokinetic contractile ring Microfilaments actin filaments are composed of globular actin proteins aligned into two twisted protofilaments Like MTs microfilaments have a distinct polarity Actin is more likely to be added to the plus end Microfilament MF Growth and Disassembly Actin is an ATPase Actin ATP is added to both ends faster growth at plus end After incorporation to a MF ATP is hydrolyzed to ADP causing a conformation change that destabilizes the MF Treadmilling and dynamic instability are dependent on nucleotide hydrolysis Some microfilaments are nucleated from actin nucleating proteins near the plasma membrane Microfilament behavior is modified by actin binding proteins Actin in action the three steps of cell crawling are actin dependent These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute 1 Actin polymerization at the leading edge of the cell results in the protrusion of lemellipodia and filopodia Branched actin networks in lemellipodia are nucleated by ARP complexes Growth of unbranched microfilaments in filopodia and other structures is promoted by formins Formins promote the addition of actin monomers 2 Integrins bind to the extracellular proteins and internal microfilaments Integrins transmembrane proteins that interact with the crawling cell s environment connected to actin filaments 3 Internal contraction of the cell is mediated by myosin II an actin dependent motor

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