TAMU BICH 410 - Transmembranes and the Flu (2 pages)

Previewing page 1 of 2 page document View the full content.
View Full Document

Transmembranes and the Flu



Previewing page 1 of actual document.

View the full content.
View Full Document
View Full Document

Transmembranes and the Flu

269 views

Finishing transmembrane transport and introduction to Influenza


Lecture number:
26
Pages:
2
Type:
Lecture Note
School:
Texas A&M University
Course:
Bich 410 - Comprehen Biochem I
Edition:
2

Unformatted text preview:

F BICH 410 Lecture 26 Outline of Last Lecture Transport Membranes Outline of Current Lecture Simple diffusion v passive transport Glut transport facilitated diffusion carrier protein o Must accumulate glucose in epithelial cells using 2Na and glucose Na goes down its conc gradient and drags the glucose along against its conc gradient o Then Na K pump causes Na to be pushed back out Active transport o Ca ATPase UNIPORT calcium is used as messenger triggering response Ca conc is low in cell 4x lower Kept low to prevent phosphate complexation that will precipitate Sarcoplasmic reticulum is where Ca stored Ca binds and triggers phosphorylation and conformation change phosphorylated form has low affinity for Ca and it is released Phosphate is then hydrolyzed Dephosphorylated form changes conformation and has high affinity for Ca o H K ATPase Hydration of CO2 water carbonic anhydrase bicarbonate and protons Protons then pumped out and K comes in charge remains the same Cl comes from KCl Excess protons peptic ulcers Histamine derivative of histidine activates this pump causing production of HCl Proton pump inhibitors competes with histamine However most ulcers actually caused by H ploryi bacteria o ABC transporters bind ATP an undergo hydrolysis but not a conformation change Generally used for pumping hydrophilic molecules Have been used for the transport of chemotherapy drugs out of cell found to play a role in drug resistance Have TMD that varies in shape and seq and allows the transporter to be specified NBD gates and opens to let things flow in very similar across all transporters Understand drug mechanism can then develop drug treaments These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Cystic fibrosis transmembrane conductance regulator pumps out Cl Na and water defect causes thick mucus Important to function of sweat glands Flu o o o o o Pandemics Russian Flu 1889



View Full Document

Access the best Study Guides, Lecture Notes and Practice Exams

Loading Unlocking...
Login

Join to view Transmembranes and the Flu and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Transmembranes and the Flu and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?