TAMU BICH 410 - Membranes (3 pages)

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Finishing up Membrane characteristics and structure

Lecture number:
Lecture Note
Texas A&M University
Bich 410 - Comprehen Biochem I

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BICH 410 1st Edition Lecture 24 Outline of Last Lecture I Membrane Structure Current Lecture Test info know how mechanisms work that were gone over in class should be able to compare membrane protein characteristics with globular and fibrous proteins Proteins found on cytoplasmic side of membrane Thioester connects to membrane via cysteine N myristotyltransferase link is non reversible and is a target for anti parastitic drugs Palmitoyl thioesterase catalyzes reversible additions where protein participate in transmembrane signaling GPI phospholipid such as phosphotidyl inositol modified sugar with glycosylation and protein attached o Always on outside of cell extracellularly located Lipid asymmetry can have protein only on inside or only on outside same with lipids o More sphigomyeline on outside less inside Lipid asymmetry phospholipids are synthesized on or near interior of membrane o ATP dependent flippase outer to inner o ATP dependent floppase inner to outer Both nonequilibrium distribution of phospholipids o Bidirectional scramlase inner to outer in order to produce equilibrium distb Temperature dependence of fluidity of a bilater o Below transition temp bilayer becomes gel like solid solid order state o Above transition temp bilayer is liquid crystal liquid order state o Transition temp depends on chain length and degree of sat Increase in Carbon increase in melting point Increase in double bonds decrease in melting temp Cholesterol broadens temp range of phase transition o As temp increases increase in composition of long chain saturation fatty acids o As temp decreases increase in composition of long chain unsaturation fatty acids Membrane Rafts lipids and protein laterally organized forming microdomains of liquid order states o Protein rich in lipid aggregates that move in sea of phospholipids o High in sphingolipids and cholesterol o A number of transport and cell surface receptor proteins are associated with lipid raft o Many viruses associate w lipid

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