TAMU BICH 410 - Transmembrane Transport (3 pages)

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Transmembrane Transport



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Transmembrane Transport

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Introduction to transmembrane transport


Lecture number:
25
Pages:
3
Type:
Lecture Note
School:
Texas A&M University
Course:
Bich 410 - Comprehen Biochem I
Edition:
2

Unformatted text preview:

F BICH 410 Lecture 25 Outline of Last Lecture Enzyme Regulation Membranes Outline of Current Lecture Transport Membrane o Diffusion of molecule from one side to another o Chemical potential deltaG RTln Ad As o Electric potential charge of ion x faraday s constant 96 465 x membrane potential o Change in free energy Electrochemical potential chemical electrical potential o membrane potential is the potential inside potential outside negative inside negativity greater cytosol inside if analyzing more than one molecule must multiply by total number if ion moves from inside to out then the sign changes but not if moves from outside to inside Transport o Mediated 1 passive mediated facilitated transport or 2 active transport requires energy Facilitated diffusion proteins help to increase rate of transport eventually reaches saturation and can perform uniport symport or antiport o Nonmediated simple diffusion such as water steroids and O2 o Channels transport through pores with high selectivity and can be gated rapid flux through channels Na K Cl K more permeable than N Channels lined with carbonyls which replace water ions around K Na is too small to interact with channel 2 K can be in channel at once o Aquaporins allow high rate of water transport Lined with hydrophobic groups allowing fast transport of water because of repulsion o Carrier transport undergoes structural change pumps or transporters Glut Transporter carrier protein Glut1 4 specific for glucose and Glut5 specific for fructose critical for glucose transport These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute o o o Gated Ion Channels gating ligand gated for extracellular ligands ie neurotransmitters or for voltage gated ion channels used in membrane potential Nicotinic acetylcholine receptor Binding of acetylcholine opens allowing Na in at post synaptic clef Nerve impulses high Na outside and K inside neuron



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