Chromosome Geography LectureChromosome Geography @ CaltechChromosome Geography: Genomic vs. physical positionFluorescence In-Situ Hybridization (FISH)Schemes for Mapping Chromosome GeographyFluorescent ProteinsSlide 7Slide 8Quantifying the GeographyThe Immune SystemThe Immune SystemThe Chromosome as a Polymer BlobHigher Order StructureAtomic-Level Structure of the NucleosomeChromosome Geography in VibrioSlide 16Chromosome Geography LectureChromosome Geography @ CaltechSturtevant and MorganBenzerChromosome Geography: Genomic vs. physical positionCremer and CremerLucy ShapiroFluorescence In-Situ Hybridization (FISH)http://www.microscopyu.com/articles/fluorescence/insitu/brennerinsitu.htmlSchemes for Mapping Chromosome GeographyGitai et al, 2005Fluorescent Proteinshttp://www.tsienlab.ucsd.edu/Images/General/IMAGE%20-%20Wreath%202002.jpgYokota et al, 1995Quantifying the GeographyGasser, Science 2002Quantifying the GeographyHeun, Gasser, Science 2001Bystricky, Gasser, PNAS 2004Quantifying the GeographySachs et al.The Immune SystemThe Immune SystemKees Murre, UCSDThe Chromosome as a Polymer Blobb=2PHigher Order StructureAtomic-Level Structure of the NucleosomeoriCIoriCIIxyProbabilityProbabilityxyReplication origins are confined!(Theriot et al.)Chromosome Geography in VibrioVibrio Distributions: theory and experimentModel:0.8moriCIoriCIILong axis Perpendicular
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