CALTECH APH 161  Molecular Motors (17 pages)
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Molecular Motors
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 17
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 California Institute of Technology
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 Aph 161  Physical Biology of the Cell
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APh161 Lecture 13 Molecular Motors Rob Phillips California Institute of Technology Molecular Motors Mitotic Spindle Organization Cilia and Flagella Assembly and Dynamics Vesicle Transport Formation of Golgi and ER Networks Rogues Gallery of Motor Action Rotary Motors Show Berg movie Show Yasuda et al movie Rogues Gallery of Motor Action Translocation Rogues Gallery of Motor Action Translational Motor 1 Rogues Gallery of Motor Action Translational Motor 2 Muscles See Hugh Huxley review on website Rogues Gallery of Motor Action Translational Motor 2 Muscles Heuser lab Washington University Organellar Transport Hirokawa Science 1998 Rogues Gallery of Motor Action Translational Motor 2 Translational Motors Kinesin Speed 850 nm s ATPase 44 0 1 s Myosin V Speed 350 nm s ATPase 5 0 1 s Dynein Speed 1250 nm s ATPase 2 0 1 s ALL INVOLVED IN VESICLE TRANSPORT How We Know Gliding Motility Assays Show Vale movie Dynamics of Molecular Motors Science Vol 300 Issue 5628 2061 2065 27 June 2003 Yildiz et al Show Gelles Selvin movie Stepping Kinetics Spudich et al PNAS 2000 Kinesin Data Fisher and Kolomeisky PNAS Fig 3 Kinesin velocity as a function of ATP under external loads F fixed by a force clamp The plots from the top down are for F 0 1 05 3 59 4 60 and 5 63 pN respectively Data from Block and colleagues 9 solid curves N 2 fits dashed curves N 2 predictions see text Kinesin Data continued Fig 4 Fits to the data of Block and colleagues 9 and predictions for velocity as a function of load for fixed concentrations of ATP Note the inflection points at low ATP and convex profile at saturating ATP Fisher and Kolomeisky PNAS Kinesin Randomness Data Fig 5 Randomness data from Block and colleagues 9 and theoretical fits A as a function of external load F at fixed ATP note that the two data points at F 5 7 pN and ATP 2 mM appear separately in Block and coworkers see figure 4 a and b of ref 9 respectively and B as a function of ATP at fixed loads of from top down F 5 69 pN 5 35 and 4 60 pN dashed line predictions 3 59 pN and 1 05 pN What do we mean by the states
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