Chromosome Geography LectureChromosome Geography @ CaltechChromosome Geography: Genomic vs. physical positionFluorescence In-Situ Hybridization (FISH)Schemes for Mapping Chromosome GeographyFluorescent ProteinsSlide 7Slide 8Quantifying the GeographyThe Immune SystemSlide 11The Chromosome as a Polymer BlobHigher Order StructureAtomic-Level Structure of the NucleosomeChromosome Geography in VibrioSlide 16Chromosome Geography LectureChromosome Geography LectureChromosome Geography @ CaltechChromosome Geography @ CaltechSturtevant and MorganBenzerChromosome Geography: Genomic vs. Chromosome Geography: Genomic vs. physical positionphysical positionCremer and CremerLucy ShapiroFluorescence In-Situ Hybridization Fluorescence In-Situ Hybridization (FISH)(FISH)http://www.microscopyu.com/articles/fluorescence/insitu/brennerinsitu.htmlSchemes for Mapping Chromosome Schemes for Mapping Chromosome GeographyGeographyGitai et al, 2005Fluorescent ProteinsFluorescent Proteinshttp://www.tsienlab.ucsd.edu/Images/General/IMAGE%20-%20Wreath%202002.jpgYokota et al, 1995Quantifying the GeographyQuantifying the GeographyGasser, Science 2002Quantifying the GeographyQuantifying the GeographyHeun, Gasser, Science 2001Bystricky, Gasser, PNAS 2004Quantifying the GeographyQuantifying the GeographySachs et al.The Immune SystemThe Immune SystemThe Immune SystemThe Immune SystemKees Murre, UCSDThe Chromosome as a Polymer BlobThe Chromosome as a Polymer Blobb=2PHigher Order StructureHigher Order StructureAtomic-Level Structure of the Atomic-Level Structure of the NucleosomeNucleosomeoriCIoriCIIxyProbabilityProbabilityxyReplication origins are confined!(Theriot et al.)Chromosome Geography in VibrioChromosome Geography in VibrioVibrio Distributions: theory and Vibrio Distributions: theory and experimentexperimentModel:0.8moriCIoriCIILong axis Perpendicular
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