LS4 Syllabus - Fall 2004 Lec. 1: MWF 10:00-10:50 am Franz 1178 Lec. 2: MWF 11:00-11:50 pm Franz 1178 Instructors: Dr. Steve Jacobsen, Office LS3229, Office hours Friday 12-2, LS3215. Dr. Lianna Johnson, Office LS3209, Office hours Thursday 1-3 pm Course Materials. Genetics, from Genes to Genomes , 2nd Edition, Hartwell et. al. 2004 Optional Study Guide/Solutions Manual with detailed problem solutions. Interactive Genetics, CD-ROM and workbook LS4 Reader, Course Reader Material, 1141 Westwood Boulevard Administrative matters. For enrollment, illness absences or other questions that do not directly pertain to the material covered in the course contact Tammy Johnson [email protected], or Mark Gray [email protected] in 2305 Life Sciences, 310 825-6614. Grading. Your grade will be determined on a curve, with a maximum of 345 pts. There will be 8 quizzes (5 pts each, lowest score dropped), a Midterm (150 pts), a 10 pt take home quiz, and a Final (150 pts). Regrades will only be considered within one week after being passed back, and only for exams written in permanent ink. Calculators are OK to use on the exams, but no graphing calculators. Discussion Sections. This is a time to go over concepts, ask questions and do problem-solving with your TA. Quizzes will be given at the end of each discussion section. You must attend the one you’re enrolled in or change with permission of TA. Assignments. Your quizzes will be taken directly from your weekly problem assignments except the first week. Problems will be from both the Interactive Genetics CD-ROM/Workbook and from the back of each chapter in your text. If you are in need of a computer, you can utilize the Science Learning Center computer facility located on the fourth floor south wing of Young Hall, www.nslc.ucla.edu Course Web Site. www.lsic.ucla.edu/classes/fall04 Contains syllabus, problem assignments, practice midterms,keys and powerpoints with sound after each lecture. These can be viewed directly or you can download a zipped file. Bulletin board. Questions pertaining to course material and assigned problems should be posted on the course bulletin board, which will be answered by a TA each day. Week 1; Yana, 2; Dmitry, 3; Amy, 4; Matt, 5; Carey, 6; Emily, 7; John, 8; Katy, 9; Aimee, 10; Rick 11; Ian.Lecture Day Date Topic Chapter Pages Quiz 1 F 10/1 Introduction/Mendel 1 and 2 1-12,13-37 2 M 10/4 Probabilities, Pedigrees 2 3 W 10/6 Genotype/phenotype 3 43-53 4 F 10/8 Genotype/phenotype 3 53-69 1 5 M 10/11 Mitosis/Meiosis 4 77-96 6 W 10/13 X Chromosome Inheritance 4 98-106 7 F 10/15 Gene linkage 5 113-120 2 8 M 10/18 Gene linkage 5 121-125 9 W 10/20 Gene linkage 5 125-127,129-132 10 F 10/22 Bacterial Genetics/Conjugation 14 487-501 3 11 M 10/25 Bacterial Genetics/Conjugation 14 501-505 12 W 10/27 Bacterial Genetics/Conjugation 14 505-507 13 F 10/29 Bacterial Genetics/Transduction 14 507-519 4 M 11/1 Review W 11/3 Thursday Midterm 5-7 PM 14 F 11/5 RII/complementation 7 206-213 15 M 11/8 One Gene/One Enzyme 7 213-225 16 W 11/10 Genetic Code Mutations 8 8 239-243 264-268 17 F 11/12 Diseases associated with Chromosomal Mutations 13 441-468 5 18 M 11/15 Transposition Aneuploidy 13 460-468 19 W 11/17 Population Genetics 20 677-682 20 F 11/19 Population Genetics 20 11 687-692 371-380 6 21 M 11/22 Detection of Genotypes RFLP 11 371-385 402-404 22 W 11/24 DNA fingerprinting 11 386-396 F 11/26 Thanksgiving Take home 23 M 11/29 Positional Cloning 11 387-396 7 24 W 12/1 Triplet diseases 7 11 199-203 384-385 25 F 12/3 Gene Replacement 744-745 849-853 26 M 12/6 Epigenetics 12 428-431 27 W 12/8 TBA F 12/10 review 8 12/13 Final Exam 6:30-9:30PMReading and Problem assignments LS4 Fall 2003 Steve Jacobsen Topic Reading assignment Text book Problems CD/Workbook Problems Mendel, Probabilities and Pedigrees. Chapt 1, pp 1-12 Chapt 2, pp 13-37 I, II, and III, 1- 30, 32a. Mendelian Problems 1-6. Pedigrees & Probabilities Problems 1-7. Relationship of Genotype and Phenotype. Chapt 3, pp 43-69 I, II, and III, 1-9, 10a-b, 11-28, 30-35. Genotype/Phenotype Problems 1-7. Meiosis and Mitosis X linked inheritance. Chapt 4, pp 77-106, Dont worry about specifics of gametogenesis in humans, pp 95-98. I, II, and III, 1-7, 8 a-g, 9-13, 17 a-c, 18-23, 25-34. Tutorials on Mitosis and Meiosis, and Problems 1-4. X-Linked Inheritance Problems 1-5. Fly Lab Problems 1-6 Linkage and Mapping. Chapt 5, pp 113-132, Skip page 128 interference. Skip Tetrad analysis, starting on p 132. I, II, 2-9, 11-14, 16-17, 18a-c, 19, 21a-b, 22-23, 32a-h. Linkage Problems 1-6 Bacterial and Phage Genetics. Chapt 14, pp 487-519. II and III, 1-3, 9-14, 15a, 18-19. Bacterial Genetics tutorials. Conjugation Problems 1-5. Transduction Problems 1-4. Quizzes 1. Concepts and terms from Lecture 1, and Chapter 2. 2. Chapter 2 problems 3,5,7,9,11,13,15,17,19,21,23,25,27,29. Chapter 3 problems 3,5,7,9,11,13,15,17,19,21,23. Mendelian Problems 1-6. Pedigrees & Probabilities Problems 1-7. Genotype/Phenotype Problems 1-7. 3. Chapter 4 problems 3,5,7,9,11,13,17a-c,19,21,23,25,27,29,31,33. Mitosis and Meiosis Problems 1-4. X-Linked Inheritance Problems 1-5. Fly Lab Problems 1-6. 4. Chapter 5 problems 3,5,7,9,11,13,17,19,21a-b,23. Linkage Problems 1-6. Mistakes in assigned problems. • Chapter 2, problem 23c, brief answer section in book says all others could be AA or Aa, but that’s wrong because II-1, II-2, and II-3 must also be carriers. • Chapter 2, problem 29b, brief answer section in book is wrong, solution manual correct. Answer is [(0.9)(0.5) + (0.1)(2/3)] X [(0.9)(0.5) + (0.1)(2/3)] X 1/4 = 0.0667. • Chapter 3, problem 3, brief answer section in book is ambiguous. Answer is cr cw X cr cw gives 1/2 cr cw yellow; 1/4 cr cr red; 1/4 cw cw white. • Chapter 3, Problem Number 8, part (a), mistake in the solutions manual. The answer states that "The only male fitting these requirements is male c whose phenotype is B,MN,Rh+". The answer should read "The only male fitting these requirements is male d, whose phenotype is B, MN, Rh+". • Chapter 4, problem 27, III-1 must be XCB Xcb, since she must have inherited Xcb from her affected father. This is