1 LS4 Syllabus - Fall 2006 Lectures MWF 12:00-12:50 PM LaKretz 110 MWF 1:00-1:50 PM LaKretz 110 Instructors: Dr. Steve Jacobsen, Office LS3229, Office hours Thurs 10-12, LS3215. Dr. Alvaro Sagasti, Office LS4227. Course Materials. Genetics, from Genes to Genomes , 2nd Edition, Hartwell et. al. 2004 Optional Study Guide/Solutions Manual with detailed problem solutions. Interactive Genetics, CD-ROM and workbook LS4 Reader, Course Reader Material, 1141 Westwood Boulevard Administrative matters. For enrollment, illness absences or other questions that do not directly pertain to the material covered in the course contact Lily Yanez at [email protected] in 2305 Life Sciences Building, 310-825-6614. Grading. Your grade will be determined on a curve, with a maximum of 335 pts. There will be 8 quizzes (5 pts each, lowest score dropped), a Midterm (150 pts), and a Final (150 pts). Regrades will only be considered within one week after being passed back, and only for exams written in permanent ink. Calculators are OK to use on the exams, but no graphing calculators. Discussion Sections. This is a time to go over concepts, ask questions and do problem-solving with your TA. Quizzes will be given at the end of each discussion section. You must attend the one you’re enrolled in or change with permission of TA. Assignments. Your quizzes will be taken directly from your weekly problem assignments except the first week. Problems will be from both the Interactive Genetics CD-ROM/Workbook and from the back of each chapter in your text. If you are in need of a computer, you can utilize the Life Sciences Instructional Computing Lab facility at 2127 Life Sciences Building. Course Web Sites. Syllabus, problem assignments, practice midterms, keys, powerpoints and office hours are at http://www.mcdb.ucla.edu/research/jacobsen/LabWebSite/jacobsenclasses.html. Other information and the course bulletin board are at http://www.lsic.ucla.edu/classes/fall06/. Podcasts of the lectures are at http://www.oid.ucla.edu/webcasts/courses. Password is XXXX Audio and video can be viewed on the web or downloaded to your iPod or video iPod. Bulletin board. Questions pertaining to course material and assigned problems should be posted on the course bulletin board, which will be answered by a TA each day (24 hour turn around). Week 1 and 2 = Georgeann, 3 = Jamie, 4 = Lydia, 5 = Matthew, 6 and 7= Nicole, 8 =Peter, 9 = Ryan, 10 = Tim.2 Lecture Day Date Topic Chapter Pages Quiz 1 F 9/29 Introduction/Mendel 1 and 2 1-12,13-37 2 M 10/2 Probabilities, Pedigrees 2 3 W 10/4 Genotype/phenotype 3 43-53 4 F 10/6 Genotype/phenotype 3 53-69 1 5 M 10/9 Mitosis/Meiosis 4 77-96 6 W 10/11 X Chromosome Inheritance 4 98-106 7 F 10/13 Gene linkage 5 113-120 2 8 M 10/16 Gene linkage 5 121-125 9 W 10/18 Gene linkage 5 125-127,129-132 10 F 10/20 Bacterial Genetics/Conjugation 14 487-501 3 11 M 10/23 Bacterial Genetics/Conjugation 14 501-505 12 W 10/25 Bacterial Genetics/Conjugation 14 505-507 13 F 10/27 Bacterial Genetics/Transduction 14 507-519 4 14 M 10/30 Finish Bac. Gen. Review Eval W 11/1 Problem solving clinics/TAs 1 F 11/3 Sagasti Lecture Friday 11/3 Midterm 5-7 PM 2 M 11/6 Sagasti Lecture 3 W 11/8 Sagasti Lecture F 11/10 Veteran’s Day 5 4 M 11/13 Sagasti Lecture 5 W 11/15 Sagasti Lecture 6 F 11/17 Sagasti Lecture 6 7 M 11/20 Sagasti Lecture 8 W 11/22 Sagasti Lecture F 11/24 Thanksgiving 9 M 11/27 Sagasti Lecture 7 10 W 11/29 Sagasti Lecture 11 F 12/1 Sagasti Lecture 12 M 12/4 Sagasti Lecture 13 W 12/6 Sagasti Lecture 14 F 12/8 Review? 8 12/11 Final Exam 6:30-9:30PM3 Reading and Problem assignments LS4 Fall 2006 Steve Jacobsen Topic Reading assignment Text book Problems CD/Workbook Problems Mendel, Probabilities and Pedigrees. Chapt 1, pp 1-12 Chapt 2, pp 13-37 I, II, and III, 1- 30, 32a. Mendelian Problems 1-6. Pedigrees & Probabilities Problems 1-7. Relationship of Genotype and Phenotype. Chapt 3, pp 43-69 I, II, and III, 1-9, 10a-b, 11-28, 30-35. Genotype/Phenotype Problems 1-7. Meiosis and Mitosis X linked inheritance. Chapt 4, pp 77-106, Dont worry about specifics of gametogenesis in humans, pp 95-98. I, II, and III, 1-7, 8 a-g, 9-13, 17 a-c, 18-23, 25-34. Tutorials on Mitosis and Meiosis, and Problems 1-4. X-Linked Inheritance Problems 1-5. Fly Lab Problems 1-6 Linkage and Mapping. Chapt 5, pp 113-132, Skip page 128 interference. Skip Tetrad analysis, starting on p 132. I, II, 2-9, 11-14, 16-17, 18a-c, 19, 21a-b, 22-23, 32a-h. Linkage Problems 1-6 Bacterial and Phage Genetics. Chapt 14, pp 487-519. II and III, 1-3, 9-14, 15a, 18-19. Bacterial Genetics tutorials. Conjugation Problems 1-5. Transduction Problems 1-4. Quizzes 1. Concepts and terms from Lecture 1, and Chapter 2. 2. Chapter 2 problems 3,5,7,9,11,13,15,17,19,21,23,25,27,29. Chapter 3 problems 3,5,7,9,11,13,15,17,19,21,23. Mendelian Problems 1-6. Pedigrees & Probabilities Problems 1-7. Genotype/Phenotype Problems 1-7. 3. Chapter 4 problems 3,5,7,9,11,13,17a-c,19,21,23,25,27,29,31,33. Mitosis and Meiosis Problems 1-4. X-Linked Inheritance Problems 1-5. Fly Lab Problems 1-6. 4. Chapter 5 problems 3,5,7,9,11,13,17,19,21a-b,23. Linkage Problems 1-6. Mistakes in assigned problems. • Chapter 2, problem 23c, brief answer section in book says all others could be AA or Aa, but that’s wrong because II-1, II-2, and II-3 must also be carriers. • Chapter 2, problem 29b, brief answer section in book is wrong, solution manual correct. Answer is [(0.9)(0.5) + (0.1)(2/3)] X [(0.9)(0.5) + (0.1)(2/3)] X 1/4 = 0.0667. • Chapter 3, problem 3, brief answer section in book is ambiguous. Answer is cr cw X cr cw gives 1/2 cr cw yellow; 1/4 cr cr red; 1/4 cw cw white. • Chapter 3, Problem Number 8, part (a), mistake in the solutions manual. The answer states that "The only male fitting these requirements is male c whose phenotype is B,MN,Rh+". The answer should read "The only male fitting these requirements is male d, whose phenotype is B, MN, Rh+". • Chapter 4, problem 27, III-1 must be XCB Xcb, since she must have inherited Xcb from her affected father. This is correct in Solutions Manual, but wrong in brief answer section in textbook. • Chapter 5 number 11b. Only wrong in the answer in the back of the text, the solutions manual is