1LS4 Syllabus - Fall 2009 Lectures MWF 12:00-12:50 PM LaKretz 110 MWF 1:00-1:50 PM LaKretz 110 Instructors: Dr. Steve Jacobsen, Office LS3229, Office hours Tuesday 9:50-11:40, LS3215. Dr. Alvaro Sagasti, Office BSRB 450B. Office hours to be announced. Course Materials. Genetics, from Genes to Genomes , 3rd Edition, Hartwell et. al. Optional Study Guide/Solutions Manual with detailed problem solutions. Interactive Genetics, CD-ROM and workbook LS4 Reader, Course Reader Material, 1137 Westwood Boulevard Administrative matters. For enrollment, illness absences or other questions that do not directly pertain to the material covered in the course contact Lily Yanez or Jane Park at [email protected] in 2305 Life Sciences Building, 310-825-6614. Grading. Your grade will be determined on a curve, with a maximum of 405 pts. There will be 8 quizzes (15 pts each, lowest score dropped, total 105 pts), a Midterm (150 pts), and a Final (150 pts). Regrades will only be considered within one week after being passed back, and only for exams written in permanent ink. Calculators are OK to use on the exams, but no graphing calculators. Discussion Sections. This is a time to go over concepts, ask questions and do problem-solving with your TA. Quizzes will be given at the end of each discussion section. You must attend the one you’re enrolled in or change with permission of TA. Assignments. For the first half of the course, problems will be from the Interactive Genetics CD-ROM/Workbook and from the back of each chapter in your text. For the second half of the course, problem sets will be handed out in class and posted on the course web site. Assigned problems will be a good indication of the types of problems that will appear on the quizzes. If you are in need of a computer, you can utilize the Life Sciences Instructional Computing Lab facility at 2127 Life Sciences Building. Course Web Sites. Syllabus, problem assignments, practice midterms, keys, powerpoints and office hours are at http://www.mcdb.ucla.edu/Research/Jacobsen/LabWebSite/P_Classes.shtml. Other information and the course bulletin board are at http://www.lsic.ucla.edu/classes/fall09/, and http://ccle.ucla.edu/course/view/09F-LIFESCI4-1. Podcasts of the lectures are at http://www.oid.ucla.edu/webcasts/courses. Audio and video can be viewed on the web or downloaded and viewed on your computer, iPod, or iPhone. Bulletin board. Questions pertaining to course material and assigned problems should be posted on the course bulletin board, which will be answered by a TA each day (24 hour turn around). Week 1 = Stephanie, 2 = Nicole, 3 = Ann, 4 = Matt, 5 = Krishna, 6 = Stephanie, 7 = Nicole, 8 = Ann, 9 = Matt, 10 = Krishna. TA contact information. Office hours will be posted on WEB. NAME EMAIL LAB Stephanie Cole [email protected] Andrew Diener Nicole Yu [email protected] Beth Lazzazera Ann Cavanaugh [email protected] Jau-nian Chen Matthew Denholtz [email protected] Kathrin Plath Krishna Chodavarapu [email protected] Matteo Pellegrini2 Lecture Day Date Topic Chapter Pages Quiz 1 F 9/25 Introduction/Mendel 1, 2 1-12,13-39 2 M 9/28 Probabilities, Pedigrees 2 3 W 9/30 Genotype/phenotype 3 45-56 4 F 10/2 Genotype/phenotype 3 56-74 1 5 M 10/5 Mitosis/Meiosis 4 81-103 6 W 10/7 X Chromosome Inheritance 4 105-114 7 F 10/9 Gene linkage 5 123-131 2 8 M 10/12 Gene linkage 5 131-135 9 W 10/14 Gene linkage 5 135-138,139-142 10 F 10/16 Bacterial Genetics/Conjugation 15 539-556 3 11 M 10/19 Bacterial Genetics/Conjugation 15 556-560 12 W 10/21 Bacterial Genetics/Conjugation 15 561-563 13 F 10/23 Bacterial Genetics/Transduction 15 563-574 4 14 M 10/26 Finish Bac. Gen. Review Eval W 10/28 Problem solving clinics/TAs Midterm 5-6:50 PM Thur, Oct 29, 2009 1 F 10/30 Complementation testing reveals that genes are distinct entities 7 224-232 2 M 11/2 One gene makes one protein 7 232-238 3 W 11/4 The genetic code 8 255-265 4 F 11/6 Hardy-Weinberg populations 21 757-662 5 5 M 11/9 Evolution alters allele distributions 21 762-773 W 11/11 Veterans Day Holiday 6 F 11/13 Positional cloning in humans 11 408-419 6 7 M 11/16 Molecular approaches to positional cloning 11 391-400, 404-406 8 W 11/18 Transgenic animals 11 415 9 F 11/20 Gene replacement in mice and yeast 20 721-723 10 M 11/23 Model organisms and mutagenesis screens TBA 7 11 W 11/25 Haploid vs diploid mutagenesis TBA 12 F 11/27 Thanksgiving Holiday 13 M 11/30 Hermaphrodite mutagenesis TBA 14 W 12/2 Understanding cell death in worms TBA F 12/4 TA Review 8 Final Exam 11:30-2:30 December 7, 2009 Reading and Problem assignments3 Topic Reading assignment Text book Problems CD/Workbook Problems Mendel, Probabilities and Pedigrees. Chapt 1, pp 1-12 Chapt 2, pp 13-39 I, II, and III, 1- 35, 36a. Mendelian Problems 1-6. Pedigrees & Probabilities Problems 1-6. Relationship of Genotype and Phenotype. Chapt 3, pp 45-74 I, II, and III, 1-11, 12a-b, 13-36, 38-39. Genotype/Phenotype Problems 1-7. Meiosis and Mitosis X linked inheritance. Chapt 4, pp 81-114, Dont worry about specifics of gametogenesis in humans, pp 103-105. I, II, and III, 1-18, 20a-g, 21a-c, 23-29, 31-40. Tutorials on Mitosis and Meiosis, and Problems 1-4. X-Linked Inheritance Problems 1-5. Fly Lab Problems 1-6 Linkage and Mapping. Chapt 5, pp 123-142, Skip page 138 interference. Skip Tetrad analysis, starting on p 142. I, II, 2-9, 11-13, 14a-h, 15, 17-19, 20a-c, 21-22, 23a-b, 24-27. Linkage Problems 1-6 Bacterial and Phage Genetics. Chapt 14, pp 539-574. II and III, 1-3, 5-6, 10-14, 16-17, 19-21. Bacterial Genetics tutorials. Conjugation Problems 1-5. Transduction Problems 1-4. First four Quizzes 1. Concepts and terms from Lecture 1, and Chapter 2. 2. Chapters 2 and 3 odd numbered assigned problems. Interactive Genetics: Mendelian Problems 1-6. Pedigrees & Probabilities Problems 1-6. Genotype/Phenotype Problems 1-7. 3. Chapter 4 odd numbered assigned problems. Interactive Genetics: Mitosis and Meiosis Problems 1-4. X-Linked Inheritance Problems 1-5. Fly Lab Problems 1-6. 4. Chapter 5 odd numbered assigned problems. Linkage Problems 1-6. Mistakes in assigned problems. • Chapter 2, problem 29c, brief answer section in