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UCLA LIFESCI 4 - lifesci4_2_syl09w

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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .LIFE SCIENCES 4GENETICSÉCOURSE INFORMATIONWINTER 2009instructor: Jay Phelan, PhDoffice: Slichter Hall 2867phone: 825.0149email: [email protected] hours: Tuesdays 1:30-2:30pm, Thursdays 2-3pmcourse web address: http://www.lsic.ucla.edu/teaching assistants: Eddie Garcia [email protected] Pham [email protected] meets: Tuesday & Thursday 11am - 12:15pm. LaKretz Hall 110. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .COURSE DESCRIPTION AND OBJECTIVESWhat is Genetics? Answering this question means answering a wide variety of relatedquestions, such as:• If every cell in your body has all of the DNA, all of the genes that make you, thenwhy don’t you have liver cells oozing out of your arm? If those skin cells haveall of the genes required to form liver cells, then why don’t they?• How accurate is DNA fingerprinting?• Why do people with red hair usually have lots of freckles?• Why are more men color-blind than women if the gene for the ability to see color isnot on the Y-chromosome?In this course we will delve deeply into the intricacies of our genes, probing the mysteries ofDNA in an attempt to better understand who we are. DNA is the hereditary material; weresemble our parents because we got our DNA from them. DNA is also the code thatinstructs our body how to do the things it does. It instructs your body to produce new bloodcells after you donate some of your old ones, to build larger muscles in response to liftingweights, to learn a new language because you want to.Why genetics? Genetics may very well be crucial to your life. Are the answers to any of thefollowing questions “yes”? If so, this class may have particular personal significance for you.Are you a farmer? Are you just a big eater? Do you want to have children? Do you wonder ifyou will go bald? Are you worried about heart disease? Do you ever take antibiotics? Wouldyou like to live longer? Would you just like to get into medical school. . .SECTION, PROBLEM SETS, AND THE QUIZZESThere is a problem set assigned for each section. They are listed on the last page of thesyllabus and refer to the “Analysis and Applications” questions at the end of the chapters inthe book. Methods of solution will be discussed in detail in the sections. You are encouragedto discuss the problems with other students. Though you are expected to complete theproblem set for each section, it will not be collected. Instead, at the beginning of each of thediscussion section meetings a quiz will be given. This quiz will take approximately 15minutes and will come from the problem set almost verbatim. There will be eight quizzes inall during the session, each worth 15 points. Your lowest quiz score will be dropped. If youmiss a quiz for any reason, that will be counted as your missed quiz. No makeup quizzes willbe given.PROBLEM SOLVING CLINICSAdditional practice problems will be posted to the course web page each week, beginning inthe second week of the quarter. Each Friday from 3-4PM, one TA will work through thesolutions to these supplementary problems at a location to be announced. Attendance atthese clinics is optional and is not intended to replace the discussion section.MIDTERMS, REGRADES, ETC.The midterms in this class—two of them—are given from 5PM to 6:30PM on Wednesday ofthe 4th and 8th weeks of the quarter. Makeup exams are NOT given. If you are unable to takeany of the exams, please see Dr. Phelan as soon as possible. Individual exam problems willnot be regraded. If you feel that an error involving five or more points was made on yourexam, submit your exam with a typed explanation of why you believe it was not scoredaccurately to the Life Sciences Core Office by Friday of the week following the exam. Theteaching staff will regrade your entire exam. Keep in mind that it is possible that your scoremight actually be decreased upon regrading. Late regrades will not be accepted. Yourregraded exam will be returned to you at the final exam. Please make a copy of it beforeturning it in.THE LIFE SCIENCES CORE OFFICEFor administrative problems relating to this course, please see Lily Yanez or Mark Katayamain the Life Sci Core Office in LS 2305 or call them at 825-6614. They can assist you withscheduling difficulties or other matters relating to any of the Life Sciences core classes.TEXTBOOK Required: Genetics: Analysis of Genes and Genomes by DL Hartl and EW Jones (7th edition),2008. (You may use the 6th edition, if necessary.) Suggested: Interactive Genetics CD-ROM, available from the student store. (Many additionalproblems, with an interactive guide to solving them.)Mean Genes. From Sex to Money to Food: Taming our Primal Instincts by TCBurnham and JP Phelan, 2001. (An account of just how pervasive the geneticinfluences on human behavior can be and how humans can fight back.)COURSE REQUIREMENTS• Midterm Exams (2 @ 150 points each) 300• Quizzes (8 @ 15 points each, lowest score dropped) 105• Final Exam (comprehensive) 250)))))))))))))))))))))))Total Points Possible: 655LECTURE SCHEDULE FOR LS4WEEK/READING DATE LECTURE TOPIC. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Ch. 1 Jan. 6 T 1. Genetics: from genotypes to phenotypes to genotypesCh. 3 Jan. 8 Th 2. Mendel and his laws. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Chs. 3, 4 Jan. 13 T 3. Pedigrees and probabilityJan. 15 Th 4. Complex gene expression: multiple alleles & dominance variations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Jan. 20 T 5. Modified Mendelian ratios, gene interactions, and genetic loadChs. 4, 8 Jan. 22 Th 6. Mitosis, meiosis and the generation of genetic variation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . …


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