notesCox1 promoted mucus secretion in stomach which protects stomach lininghelps with profusion of kidneys and allows you to get rid of excess stufencourages platelet aggregationprotects GI and KidneysFound EverywhereCox2 Pain and inflammationFound on damaged tissuePromotes feverWhat is the action of aspirin: inhibits cox1and2 irraversablyNsaids: reversibly inhibition of cox 1 and 2 (1st gen)Side efect of too much aspirin: salicysm, liver toxicity (kidneys aren’t working)Thiazides and lasix had sulfa allergy crossoverQuizContraindication to for cyclosporin: elderly, preg (inceased risk of infection - immunocompromised)ADR: kidney failureH1 and H2 : know what they do (know them)s/s with activationMOA of first gen nsaids blocks cox1and 2 (asa irreversibly, all others reversibly)Reasons why you would give cox 1 inhibitors (asa decreases risk so mi or stroke)Glucocorticoids, when stressed, increase doseADR of glucocorticoids: osterporosis, cushings syndrome, in kids growth retardation, adrenal suppression, hyperglycemiaHydrocortisone – dosing (smallest possible efective does normally, in crisis as much as needed, prolonged, smallest possible dose, stress, increase) /20-240 split up / 100-8000mg/day (always split up every two to four hours)Etanercept (enbrel)- biological dmar, pt teaching (drug-drug interaction) don’t give people live vaccines and immune
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