Hypertension drugsName Examples Use ADR DDI Other(ACE-I) ACE inhibitors “End in –PRIL”Captopril (Capoten)Enalapril (Vasotec)Benazepril (Lotensin)HF, HTN, decreases mortility post MI, renal disease, prevent stork/MI/death in high risk ptsFirst dose hypotensionDry cough (related to bradykinin)HyperkalemiaAngioedema (swelling of the mouth and throat, MEDICAL EMERGENCY)Causes renal failure (caution in renal patients)Orthostatic hypotensionDiuretics, antihypertensives,LithiumDrugs that increase K+supplements/potassium sparing diureticsNSAIDS (ibuprofen decreaseeffects of ACE) Angioedema -> medical emergencyPregnancy category X*First Dose HoTN (so take 1 st time before bed) *Cough and hyperkalemia arenot side effects of ARB (if cough w/ ACE, change to ARB).(ARBs) Angiotensin II Receptor Blockers “End in –sartan”Losartan (Cozaar) Olmesartan Candesartan (Benicar)HTNHFIncrease potassiumRenal failureAngioedemaOrthostatic hypotensionAngioedema-> medical emergencyPregnancy category XNonselective Beta blockers (Includes Beta 2 = 2 lungs) “End in –olol or –lol” *P&N (Peanut noodles)Propranolol (Inderal)Nadolol (cotgard)P&NAngina, cardiac arrhythmias, HTN, post MI, hyperthyroidismBradycardiaCNS: depression, insomnia, tiredness and fatigue (will go away)HFHypoglycemia Bronchoconstriction CCB (further decrease HR and BP)Monitor HR/BP before giving drug*Masks early warning signs ofhypoglycemia (warn diabeticsthat they may not get usual warning signs of hypoglycemia, like tachycardia)Caution in COPD/asthma ptsHypertension drugsName Examples Use ADR DDI OtherSelective beta blockersBlocks only Beta 1Metoprolol (Lopressor)Atenolol (Tenormin)M&AAngina, cardiac arrhythmias, HTN, post MI, hyperthyroidismAs you increase the dose you decrease the specificity of the beta blockers CCB (further decrease HR and BP)*Will still slow HR (warn DM pts, see above) Good for Asthmatics and DM (high dose less selectivity) Alpha1 Adrenergic Blockers“End in –azosin”Terazosin (hytrin)Doxazosin (ardura)HypertensionBPH Orthostatic HypotensionNasal congestionSexual dysfunction First dose hypotension VertigoTake at bedtime (first dose response Hypotension) -> same as ACE Calcium channel blockersVSM (vascularsmooth muscle) and HeartVerapamil (calan)Diltiazem (Cardizem)VDHTN, angina, cardiac dysrhythmias, NOT IN HF PTS (worsens it)Constipation, hypotension, bradycardia. *Verapamil (Causes 60% increase in levels of Digoxin)BB reduce HR & conductionUsed for cardiac dysrhythmias Direct effects on heart Calcium channel blockersVSM only“dipine” Nitedipine (paracardia)Amlodipine (Norvasc) N/AHTN, angina Reflex tachycardia (combine with BB to counteract)HypotensionEdemaOnly works on blood vessels *Reflex tachycardia (combine w/ BB to
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