Everything we say about NSAIDS applies to aspirin, not everything we say about aspirin applies to other NSAIDSFirst Generation NSAIDsName MOA Uses Special? ADRs Toxicity DDI/BenefitsAspirinASAInhibits C1and C2irreversible Decreaseinflammation ininflammatorydisorders(arthritis,tendonitus)Decrease mild tomoderate painDecreasefever(Adults)dysmorrheaGood for MIs,angina,angioplasty,and strokes-why we stillhave itDecrease riskfor colorectalcancerHelps withalzhiemersGI ulcers/ bleedingD/C ASA 5-7 daysbefore scheduledsurgeryRenal failureSalicylism:increased asa,tinnitus, HA,dizzinessCategory DReye’s syndrome:causes extreme liverdamage andencephalopathy/herpes andchickenpox-likeAcuteemergency =lethals/s: fever,decreasedrespirations,dehydration,acidosisTX of ASA OD,TX s/s:coolingblanket, water,DDI: anticoagulants (warfarin,heperin), steroids (increasedrisk for GI ulcers), alcohol(mainly in alcoholics, increasedrisk of GI bleed) inuprofen(decrease platelets effects ofASA – increased bleeding)TX of ASA OD, TX s/s: coolingblanket, water, Non-AspirinNSAIDsIbuprofen(motrin,advil)Indomethacin(indocin)Naproxen(anaprox,aleve)Ketorolac (toradol)Inhibits c1and c2reversable*NOTprotectiveagainst MI,Storke*NSAIDSincrease riskof MI andStroke-Gastriculceration-Bleeding-renalimpairmentBenefits: antiinflammitory,antipyretic, analgesicKetorolac (toradol) – IV/POforms (It works very quickly)Black Box Warning* only use for5 days*decrease dose if 65 y/o or >(increased bleeding and renalfailure)Everything we say about NSAIDS applies to aspirin, not everything we say about aspirin applies to other NSAIDSBenefits: Decrease inflammation, pain, feverDetrimental: GI ulcers/ bleeding, renal failure, increased bleeding(inhibits platelet aggrigation)Inhibit: cox 1 and cox
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