PHIS 206 1st EditionLecture 28Outline of Last Lecture I. Pancreatic Digestive EnzymesII. Secretion: Exocrine PancreasIII. Pancreatic LipaseIV. Three Phases of Postprandial Pancreatic SecretionV. Major Functions of the LiverVI. Bile + Control of Bile SecretionsVII. Removing GallbladderVIII. SteatorrheaIX. Gastric Bypass SurgeryOutline of Current Lecture I. Small IntestineII. Motilitya. Segmentationb. Peristalsisc. Muscularis Mucosa Contractiond. Migrating Motility (Motor) ComplexIII. SecretionIV. DigestionV. Further Digestion of Nutrients: Carbohydrates, Proteins, FatsVI. AbsorptionVII. DiarrheaCurrent LectureI. Small Intestine-Major Site for Digestion-Major Site for AbsorptionII. Motilitya. Segmentation-primary pattern during feeding-mixing of chyme with digestive juices (for digestion)-chyme comes into contact with mucosal surfaces (for absorption)b. Peristalsis-short distances-chyme pushed towards large intestineThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.-mixed in with segmentationc. Muscularis Mucosa Contraction-contractions of muscle-like cells-helps pulls nutrients from submucosal into the capillaries-villi may moved. Migrating Motility (Motor) Complex- “initial housekeeper”-main motility between meals-from stomach to small intestine-short distances, dies out, starts again where it stopped-hormone motilin may be involvedIII. Secretion-alkaline solution (aq) with mucus; but NO enzymes enzymes on the brush border of small intestine; NOT secreted-increased osmolarity cause the release watery secretionsIV. Digestion-Few enzymes synthesized by the small intestines Enterokinase: activates trypsinogen Disaccharidases: maltase, sucrase, lactase Aminopeptidases: manyV. Further Digestion of Nutrients: Carbohydrates, Proteins, Fats-Carbohydrates broken down by Disaccharidases enter epithelium as monosaccharides-Proteins can be transported as peptides or amino acids must be amino acids to exit membrane and enter blood -Fats no digestion past monoglycerides free fatty acids required for absorption intracellular triglycerides reformed and packaged into chylomicrons to enter lymphatic system, NOT bloodVI. Absorption-Volume absorbed by small intestine per day: 9000 mL≈9LVII. Diarrhea: passage of fluid fecal material -can lead to metabolic acidosis (loss of bicarbonate)-Causes bacterial or viral infection increasing motility excess of osmotically active particles (lactose) bacterial
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