PowerPoint PresentationSlide 2Slide 3Slide 4Slide 5Slide 6Slide 7Slide 8Slide 9Slide 10Slide 11Slide 12Slide 13Slide 14Slide 15Slide 16Slide 17Slide 18Slide 19Slide 20Slide 21Slide 22Slide 23Slide 24Slide 25Slide 26Slide 27Slide 28Slide 29Slide 30Slide 31Slide 32Slide 33Slide 34Slide 35Slide 36Slide 37Slide 38Slide 39Slide 40Slide 41Slide 42Slide 43Slide 44Slide 45Slide 46Slide 47Slide 48Slide 49Slide 50Slide 51Slide 52Slide 53Slide 54Slide 55Slide 56Slide 57Slide 58Slide 59Slide 60Slide 61Slide 62Slide 63Slide 64Slide 65Slide 66Slide 67Slide 68Slide 69Slide 70Slide 71Slide 72Slide 73Slide 74Slide 75Slide 76Slide 77Slide 78Slide 79Slide 80Slide 81Slide 82Slide 83Slide 84Slide 85Slide 86Slide 87Slide 88Slide 89Slide 90Slide 91Slide 92Slide 93Slide 94Slide 95Slide 96Slide 97Slide 98Slide 99Slide 100Slide 101Slide 102Slide 103Slide 104Slide 105Slide 106Slide 107Slide 108Slide 109Slide 110Slide 111Slide 112Slide 113Slide 114Slide 115Slide 116Slide 117Slide 118Slide 119Slide 120Slide 121Slide 122Slide 123Slide 124Slide 125Slide 126Slide 127Slide 128Slide 129Slide 130Slide 131Slide 132Slide 133Slide 134Slide 135Slide 136Slide 137Slide 138Slide 139Slide 140Slide 141Slide 142Slide 143Slide 144Slide 145Slide 146Slide 147Slide 148Slide 149Slide 150Slide 151Slide 152Slide 153Slide 154Slide 155Slide 156Slide 157Slide 158Slide 159Slide 160Slide 161Slide 162Slide 163Slide 164Slide 165Slide 166Slide 167Slide 168Slide 169Slide 170Slide 171Slide 172Slide 173Slide 174Slide 175Slide 176Slide 177Slide 178Slide 179Slide 180Slide 181Slide 182Slide 183Slide 184Slide 185Slide 186Slide 187Slide 188Slide 189Slide 190Slide 191Slide 192Slide 193Slide 194Slide 195Slide 196Slide 197Slide 198Slide 199Slide 200Slide 201Slide 202Slide 203Slide 204Slide 205Slide 206Slide 207Slide 208Slide 209Slide 210Slide 211Slide 212Slide 213Slide 214Slide 215Slide 216Slide 217Slide 218Slide 219Slide 220Slide 221Slide 222Slide 223Slide 224Slide 225Slide 226Slide 227Slide 228Slide 229Slide 230Slide 231Slide 232Slide 233Slide 234Slide 235Slide 236Slide 237Slide 238Slide 239Slide 240Slide 241Slide 242Slide 243Slide 244Slide 245Slide 246Slide 247Slide 248Slide 249Slide 250Slide 251Slide 252Slide 253Slide 254Slide 255Slide 256Slide 257Slide 258Slide 259Slide 260Slide 261Slide 262Slide 263Slide 264Slide 265Slide 266Slide 267Slide 268Slide 269Slide 270Slide 271Slide 272Slide 273Slide 274Slide 275Slide 276Slide 277Slide 278BIO 325 – GeneticsGenomics II WANDERED lonely as a cloudThat floats on high o'er vales and hills,When all at once I saw a crowd,A host, of golden daffodils;Beside the lake, beneath the trees,Fluttering and dancing in the breeze.Continuous as the stars that shineAnd twinkle on the milky way,They stretched in never-ending lineAlong the margin of a bay:Ten thousand saw I at a glance,Tossing their heads in sprightly dance.The waves beside them danced; but theyOut-did the sparkling waves in glee:A poet could not but be gay,In such a jocund company:I gazed--and gazed--but little thoughtWhat wealth the show to me had brought:For oft, when on my couch I lieIn vacant or in pensive mood,They flash upon that inward eyeWhich is the bliss of solitude;And then my heart with pleasure fills,And dances with the daffodils.IntroductionWhat is an organism’s genome? IntroductionWhat is an organism’s genome? What is genomics? IntroductionWhat is an organism’s genome? What is genomics? What is structural genomics?IntroductionWhat is an organism’s genome? What is genomics? What is structural genomics?What is functional genomics?IntroductionWhat is an organism’s genome? What is genomics? What is structural genomics?What is functional genomics?What is proteomics?IntroductionCytogenetic and Linkage MappingMapping refers to the experimental process of determining the relative locations of genes or other segments of DNA along individual chromosomes. Cytogenetic and Linkage MappingMapping refers to the experimental process of determining the relative locations of genes or other segments of DNA along individual chromosomes. There are three ways to determine the organization of DNA regions. Cytogenetic and Linkage MappingMapping refers to the experimental process of determining the relative locations of genes or other segments of DNA along individual chromosomes. There are three ways to determine the organization of DNA regions. Cytogenetic mapping (cytological mapping). Cytogenetic and Linkage MappingMapping refers to the experimental process of determining the relative locations of genes or other segments of DNA along individual chromosomes. There are three ways to determine the organization of DNA regions. Cytogenetic mapping (cytological mapping). Linkage mapping (genetic mapping). Cytogenetic and Linkage MappingMapping refers to the experimental process of determining the relative locations of genes or other segments of DNA along individual chromosomes. There are three ways to determine the organization of DNA regions. Cytogenetic mapping (cytological mapping). Linkage mapping (genetic mapping). Physical mapping. Cytogenetic and Linkage MappingThis figure compares genetic maps produced by the three mapping methods showing the loci for two X-linked genes in Drosophila melanogaster. Cytogenetic and Linkage MappingA goal of cytogenetic mapping is to determine the location of genes along an intact chromosome. Cytogenetic MappingIn situ hybridization is widely used to cytogenetically map the locations of genes and other DNA segments within large eukaryotic chromosomes. Cytogenetic MappingDNA of a cloned gene is used as a probe to determine the location of that gene. Cytogenetic MappingDNA of a cloned gene is used as a probe to determine the location of that gene. If the probe is fluorescently labeled, the procedure is called fluorescence in situ hybridization (FISH). Cytogenetic MappingCytogenetic MappingCytogenetic MappingCytogenetic MappingCytogenetic MappingView with a fluorescence microscope.In this experiment, six different probes were used to locate six different sites along chromosome 5 (both chromosomes of the pair are shown).Two spots are usually seen at each site because the probe binds to both sister chromatids.Linkage MappingRegions of DNA that do not encode genes can be used as molecular markers. Linkage MappingRegions of DNA that do not encode genes can be used as molecular markers. A molecular marker is a segment of DNA that is found at a specific site along a chromosome and has properties that enable it to be