BIO 326R 1st Edition Lecture 35 Outline of Last Lecture I. Immunitya. Phagocytic cells continuedi. Opsonin-dependent mechanismii. inflammationiii. cytokinesII. Adaptive immunitya. Humoral immunityb. Cellular immunityc. Antigeni. Epitoped. Antibodiesi. IgMii. IgGe. B cellsf. T cellsi. Th cellsii. Tc cellsOutline of Current Lecture I. Antigen presenting cellsa. MHC Ib. MHC IIII. Vaccinesa. Variolationb. Passive immunizationc. Active immunizationd. Why vaccines sometimes failIII. AdjuvantsCurrent LectureAntigen Presenting Cells- Most cells via MHC Io Activates cytotoxic T cellsThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.- Profession antigen presenting cells, like macrophages, dendritic cells, B cells via MHC I and MHC IIo Responsible for activating T cells and stimulating immune responseVaccines- Small pox=> variolationo = scratched skin and inoculated with cow pox and let scab to provide protection against small pox- Read slides for all info on vaccines- Passive immunization= receive monoclonal antibodyo = can recognize a single epitopeo Narrow lifetimeo Produced in the lab and received intravenously- Active immunization= live vaccineso Long lifetimeo More reliable, durable- Vaccines can sometimes failo Failure to elicit anticipated protective responseo Harmful side effectso Unexpectedly makes disease worseAdjuvants- Adjuvants= molecules that enhance immune response to an antigeno Sometimes used to aid in delivery of a vaccineo Most believe that adjuvants are the cause of vaccination side
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