BIO 326R 1st Edition Lecture 33 Outline of Last Lecture I. Immunitya. Innateb. Characteristicsc. Typesi. Anatomical barrier1. skin2. mucous membranesd. physiological factors that prevent colonizationOutline of Current Lecture I. Immunity—physiological barriera. Chemical factorsi. Acidsii. Peptiniii. Complementiv. Antimicrobial proteinsv. Cytokinesvi. Phagocytic cellsCurrent LectureImmunity—Physiological Barriers- Chemical factorso Fatty acids, lactic acidso Pepsin= digestive enzyme, degrades proteino Complement= group of proteins present in serum that, when activated, form pores in membranes Proenzyme (no enzymatic function) until they bind to a membrane (activates enzymatic function) Your cells product sugars or have proteins associated with them that block complement bindingThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute. Factor H= bind to host cells and prevent complement binding and activation Complement binding works best on gram – due to their outer membraneo Antimicrobial proteins Defensin= cAMP regulated, cationic antimicrobial peptides- Cationic—bacteria cells are negatively charged on outside so cation allows pores to form in the membrane- Change membrane permeability- Prevalent in invertebrates - Stimulate the immune systemo Cytokines= protein signals produced by the host during infection Can recruit immune cells to sites of ingection Interferon= produced by virally infected cells- induces and antiviral response (some controversy over this among microbiologists)o stops spread from cell to cell and cells become resistanto Phagocytic cells Pathogen associated molecular patterns (PAMPs)—the microbe- Bacterial cell components unique to bacteria/different from hosto LPS, peptidoglycan, formyl-methionine, teichoic acid Recognized by pattern recognition receptors (PRR)—the host- Recognize components different from their
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